ABSTRACT
Objective To evaluate the imaging findings of thoracic Castleman's disease (CD)to improve the diagnostic accuracy. Methods The imaging findings of 14 cases of thoracic CD confirmed by pathology were analyzed retrospectively.Plain and dynamic contrast-enhanced CT scans were performed in all patients before surgery.Results Among the 14 cases,10 cases were hyaline vascular type (HVT)and other 4 cases were plasma cell type (PCT).HVT-CD showed well-define,homogeneous soft-tissue lesion with different sizes of lymph nodes around the lesions in 2 cases,mottled calcification in 2 cases and coarse calcification in 1 case.Dynamic enhanced CT showed HVT-CD had obvious enhancement in arterial phase,and sustained enhancement in venous phase and delayed phase.PCT-CD all showed enlarged lymph nodes in the mediastinum and bilateral axillary,associated with interstitial pneumonia,pulmonary nodules,ground glass opacity and pleural effusion,with marked and sustained enhancement 1 case.Conclusion Thoracic HVT-CD presents equal density on CT plain scan,and obvious and durative enhanement on multiphase contrast-enhanced CT,which can be accompanied by lymphnodes around the lesions and intratumoral calcification.With the above imaging findings,we should consider the possibility of HVT-CD.CT features of PCT-CD are non-specific,a comprehensive evaluation of the clinical data should be combined,but the obviously enhanced PCT-CD can be diagnosed.
ABSTRACT
Purpose To detect the expression of osteopontin(OPN) and minkine(MK) protein in paraffin-embedded samples obtained from patients with infiltrating breast carcinoma and to analyze the relationships between their expression and clinical feature and prognosis in order to provide valuable biomarkers for the treatment and prognosis of infiltrating breast carcinoma.Methods The expression of OPN and MK was measured in 90 infiltrating breast cancer tissues and 30 hyperplastic disease of the breast by immunohistochemical PV-9000 two-step method.Results Immunohistochemical results showed that the positive rates of OPN and MK in infiltrating breast carcinoma were 71.11% (64/90) and 78.89 (71/90), respectivelyy, which were significantly higher than that in hyperplastic diseases of breast [30.00% (9/30) and 46.67% (14/30)](P0.05).The expression of MK was significantly correlated with tumor size,axillary lymph node metastasis,recurrence of tumor , the expression of p185 and TNM stage(P0.05).There was a significantly positive relationship between OPN and MK expression (r=0.274,P=0.009). TTP and OS in patients with OPN and MK positive expression were shorter than those with OPN and MK negative expression (P<0.05).Conclusions OPN and MK′s expression may correlate with the progression of breast cancer.OPN and MK′s detection may provide a theoretical basis for the diagnosis and treatment of infiltrating breast carcinoma.