ABSTRACT
The purpose of this review is to evaluate the promoting effects of amniotic membrane tissue on ulcer healing and investigate the underlying mechanism, providing new ideas for diabetic foot management. A computer-based online search of CNKI, PubMed and other databases to screen multi-center, randomized controlled trials published in high-impact journals using biological dressings, diabetic foot and other search terms. The retrieved data were analyzed and summarized. Amniotic membrane tissue and its derivatives can greatly shorten the time taken for healing of ulcer surface. This occurs possibly because they can promote angiogenesis and neural repair and prevent against infection. Moreover, the new derivatives provide great ease in use. Therefore, amniotic membrane and its derivatives provide a new tool for diabetic foot management.