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Objective:To investigate the mechanism and clinical features of pseudomembranous colitis(PMC)caused by antitubercular agents for providing a reference for its clinial treatment.Methods:One PMC case was admitted to our hospital in January 2019, and the remaining 27 cases were reported at home and abroad from January 1990 to May 2020 after the application of anti-tuberculosis drugs, all of which were obtained by literature retrieval.The domestic and foreign literature on PMC caused by antitubercular agents were reviewed.The agents causing PMC, clinical characteristics and prognosis were analyzed and summarized.Results:In this paper, 28 PMC cases caused by anti-tuberculosis drugs were reviewed.The ratio of men to women was 1.0∶1.5, with a median age of 65.5 years.The 22 cases were aged 60 years and over, accounting for 78.6 percent.The onset time of PMC symptoms in 28 patients was from 6 d to 126 d after anti-tuberculosis treatment, with a median time of 32 d. All patients immediately after diagnosis of PMC stopped all anti-tuberculosis drugs, and received metronidazole or vancomycin, with a good prognosis.Seven cases relapsed after continuing anti-tuberculosis treatment.Of them, 4 cases had no recurrence only after stopping or replacing rifampicin with other drugs.Conclusions:The incidence of PMC is increased in elderly patients with long-term use of rifampicin anti-tuberculosis treatment, and it is easy to relapse.The prolonged use of rifampicin should be avoided or replaced with other anti-tubercular agents.
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Objective:To determine the content of Chikusetsu saponin Ⅳa in the roots, stems and leaves in Panacis japonici rhizoma, and explore its development value. Methods:By using High Performance Lliquid Chromatography (HPLC) method to determine the content of Chikusetsu saponin Ⅳa in the roots, stems and leave of Panacis japonici rhizoma. Inertsil ODS-sp (4.6 mm×150 mm, 5 μm) was used as the column and the acetonitrile-0.2% phosphoric acid (35:65) as the mobile phase. The flow rate was 1 ml/min with the temperature 35 ℃ under wavelength 210 nm. Results:The linear ranged from 1-10 μg of Chikusetsu saponin Ⅳa was good ( r=0.999 5). The content of Chikusetsu saponin Ⅳa in the roof, stem and leaf were 2.169%, 0.269%, 0.169%, respectively. Conclusions:The roof of Panacis japonici rhizoma contains the highest level of Chikusetsu saponin Ⅳa followed by stem and leaf. The roof part could be used as the medical part and its stem and leaf are also valuable for further development.
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Objective@#To learn the health literacy level and its influencing factors among permanent residents in Shaanxi Province in order to improve it.@*Methods@#From July to November of 2017,multi-stage stratified cluster sampling method was used to select 15-69 year-old permanent residents in Shaanxi Province. A survey was conducted using“Chinese citizen health literacy monitoring questionnaire”issued by National Health Commission. The influencing factors for health literacy were analyzed by the multivariate logistic regression model.@*Results@#Totally 2 352 valid questionnaires were collected with a response rate of 98.00%. The health literacy level of permanent residents in Shaanxi Province was 10.54%. The levels of basic knowledge,healthy lifestyle and behaviors,and health related skills were 24.81%,9.33% and 14.52%,respectively. The levels of scientific health views,safety and first aid,health information,infectious diseases prevention,basic medical care and chronic diseases prevention were 42.81%,42.73%,19.11%,18.32%,16.27% and 8.24%,respectively. The results of multivariate logistic regression analysis showed that educational background of junior high school or above（OR：6.660-29.077,95%CI：2.050-97.355）was a promoting factor of health literacy,yet rural residency（OR=0.621,95%CI：0.442-0.872）was a constraining factor. @*Conclusion@#The heath literacy level of Shaanxi residents in 2017 was 10.54%. Educational background of junior high school or above and rural residency were influencing factors for health literacy.
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Objective:To screen differentially expressed proteins in serum proteomic patterns in patients with Rheumatoid Arthritis associated Interstitial Lung Disease by Surface enhanced laser desorption /ionization mass spectrometry with Protein Chip ,and evaluate the value of a preliminary study.Methods: WCX2 ( Weak cation exchange chip ) and Surface enhanced laser desorption/ionization mass spectrometry with ProteinChip were performed to test serum proteins in 19 Rheumatoid Arthritis associated Interstitial Lung Disease,15 Rheumatoid Arthritis patients and 13 health adults,Biomarker Wizard ,Biomarker Pattern and Spss13.0 software were used in combination to analyze the data.Results:The mass/charge ratio ( M/Z) value of 142 protein peaks were detected in serum , there were 4 proteins differentially expressed with statistical significance among them ( P<0.05;Student′s t-test ) , which were the proteins with M/Z 3382.59 ,3453.39 ,11886.0 ,5825.48;the proteins with M/Z 11689.4 ,2266.49 ,1020.22 ,4392.28 ,5074.38 and 2764.69 were selected to establish the optimal diagnostic model.The sensitivity was of was 90%(9/10),the specificity was of 90%(18/20).Conclusion: Surface enhanced laser desorption/ionization time of flight mass spectrum can screen out the significantly different proteins in serum of patients with Rheumatoid Arthritis associated Interstitial Lung Disease.As bomarkers , both of their sensitivity and specificity were high and determination have good prospects for clinical application .
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OBJECTIVE: To study the problems following implantation of nondegradable drug eluting stent, and to investigate the biocompatibility of degradable stent. METHODS: Articles were retrieved from CNKI and Pubmed with the key words of "degradable, drug-eluting stent, compatibility" in both Chinese and English from January 1999 to June 2009. Indicators including biocompatibility, endothelialization degree of coronary artery, and incidence of in-stent restenosis were evaluated. Articles related to degradable drug eluting stent were included, while articles related to other types of stent were excluded. RESULTS: Among 236 articles, 33 articles were included in the final analysis. Recently, drug stents consist of nondegradable polymer, which will be ageing and falling into small blocks in the vessels and may induce adverse effect, following long-term human body corrosion. However, degradable materials may reduce onset of adverse effect in later stage. Degradable stent may temporarily support vessel wall, smoothly keep blood flow, inhibit thrombosis in an eedy stage and newbom endomembrane proliferation in later stage, and effectively prevent acute vascular occlusion and reduce incidence of restenosis following stent implantation. CONCLUSION: Compared with nondegradable stent, degradable drug eluting stent has a great biocompatibility and a hopeful perspective.
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Objective To raise diagnostic rate of protruded lesion of gastrointestinal mucosa and to judge the precise differentiation to the depth of malignant lesion.Methods 12 cases of gastrointestinal diseases were examined by MPS combined with endoscopic examination.Results To the patients suffering protruded lesion of gastrointestinal mucosa with negative biopsy,the MPS provided a sound basis for diagnosis;To the cases of malignant lesion,findings of MPS with regard to the depth were in total concordance with that of surgical biopsy.Conclusion MPS is significanfly superior to conventional endoscopy with pathological biopsy in the differentation of protruded lesion of gastrointestinal mucosa.But in the case of malignant lesion,only the depth of infiltration of gastrointestinal wall can be correctly assessed by MPS.The value is limited in showing whole Picture for larger focus and in the identification of around lymphnodes and whether or no distal metastases in the near organs.
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Objective To observe the effects of ?1-receptor antagonist Urapidil on the size of myocardial infarction and arrhythmias in the rats model of ischemia-reperfusion(I/R) and to investigate the dose-effect relationship.Methods One hundred Sprague-Dawley rats were randomly divided into 5 groups with 20 rats each: sham operation group,I/R group and therapy group(Urapidil 3 mg/kg,6 mg/kg,12 mg/kg).Ten rats in each group were subjected to 10 min of left anterior descending branch of coronary artery ligation and 15 min of reperfusion and Urapidil was injected 5 min before the ligation.The ventricular arrhythmias of ischemia-reperfusion was observed.The other 10 rats in each group were subjected to 30 min of left anterior descending branch of coronary artery ligation and 40 min of reperfusion.Urapidil was injected 15 min before blood circulation was regained.The content of serumal enzyme and the myocardial infarct size were observed.Results Compared with the I/R group,the incidence of ventricular arrhythmias was lower and the duration of arrhythmias was significantly shorten,as well as the incidence of ventricular fibrillation(VF) and mortality was lower with the treatment of Urapidil in the therapy group.The result showed that the effect of Urapidil was of dose dependent.The release of serumal enzyme resulted from ischemia-reperfusion injury was reduced in therapy group than that of I/R group and there was no significant difference among the different dosages in the therapy group.The myocardial infarct size was significantly lower in the therapy group than that of I/R group and there was no obvious difference among the different dosages in the therapy group.Conclusion There is protective effect on the ischemia-reperfusion injury in rats with the treatment of urapidil with the dosage of 3,6 and 12 mg/kg respectively.