ABSTRACT
Background: Central mediated abdominal pain syndrome (CAPS) related functional gastrointestinal disorders (FGIDs) is a commonly seen disease. Although the efficacy of antidepressants in treatment of CAPS has been reported, yet there is still lack of typical representative drugs and sufficient clinical data. Aims: To evaluate the efficacy of duloxetine in CAPS. Methods: A total of 143 patients with CAPS from Jan. 2017 to Dec. 2019 at Qingdao Municipal Hospital were enrolled and randomly divided into duloxetine group and placebo group. Brief pain inventory (BPI) was used to evaluate the efficacy. Results: Compared with placebo group, duloxetine significantly improved the average pain, the most painful in the past 24 hours, as well as the minimum pain and present pain in the patients with CAPS, and the impact on daily life, emotion, interest in life, walking ability, sleep, interpersonal relationship, working was significantly improved in duloxetine group. 6.8% of patients in duloxetine group had treatment-induced adverse events, including nausea, dry mouth, constipation, and headache. Conclusions: Duloxetine can improve CAPS, and the safety in use is well.
ABSTRACT
Background:Colorectal polyps(CRP)has nonspecific clinical manifestation,and is closely related to the pathogenesis of colorectal cancer. Studies have shown that abnormalities of serum uric acid(UA),serum lipids are closely related to pathogenesis of CRP,but is still in controversial. Aims:To investigate the correlation between serum UA,TG, TC,LDL-C,HDL-C and incidence of CRP. Methods:A total of 142 CRP patients from Jan. 2016 to Oct. 2016 at Qingdao Municipal Hospital were enrolled,and 116 patients without CRP were served as controls. The serum levels of UA, TG,TC,LDL-C,HDL-C were determined,and correlation between UA and serum lipids was analyzed. Results:Compared with controls,serum levels of TG,UA were significantly increased in CRP patients(P<0.05),HDL-C level was significantly decreased(P<0.05),however,no significant differences in TC,LDL-C levels were found between the two groups. Serum UA level was positively correlated to TG,TC,LDL-C levels in patients with CRP(r=0.32,r=0.21, r=0.15;P<0.05),and negatively correlated to HDL-C level(r= -0.07,P<0.05). Conclusions:Increased serum TG and UA levels and decreased serum HDL-C level may be correlated to the pathogenesis of CRP. The interaction between serum UA,TG,TC,LDL-C and HDL-C may increase the risk of CRP.
ABSTRACT
Objective To investigate the effect of Williams life skills training (WLST) on preoperative anxiety and trait coping strategies in patients undergoing general anesthesia for elective surgery. Methods A total of 120 patients undergoing general anesthesia for elective surgery were randomly divided into observation group and control group according to random number table method with 60 cases each. The control group was given general preoperative nursing intervention, on the basis of which the observation group gave WLST. Before and after the intervention, the Amsterdam Preoperative Anxiety and Information Scale and Trait Coping Style Questionnaire were used to evaluate the patients. Results Before intervention, there was no significant difference between the two groups (P>0.05). After intervention, the preoperative anxiety and information needs scores of the observation group was (10.02 ± 2.53) and (4.02 ± 1.05) points respectively, while in the control group was (15.89 ± 3.20) and (7.96 ± 1.62) points respectively, the difference was statistically significant (t=7.952, 8.447, P<0.05), and negative coping score was (29.07 ± 6.14) points lower than the control group (33.86 ± 7.12) points, positive response score was (33.89 ± 7.64) points higher than the control group (29.77 ± 6.71) points, the difference was statistically significant (t = 7.647, 7.981, P <0.05). Conclusion WLST can effectively improve preoperative anxiety in patients undergoing general anesthesia and improve their coping ability, which is conducive to the successful implementation of anesthesia and surgery.