ABSTRACT
Newcastle disease virus is paramyxoviridae, Avian mumps virus genus type I, and infects more than 250 species of birds, causing huge losses on poultry farming worldwide. Numerous experiments have demonstrated that Newcastle disease virus has oncolytic activity on tumor cells and can selectively replicate in cancer cells. Thus, Newcastle disease virus is a potential therapeutic agent for cancer treatment. Some human clinical trials achieved good results. In this review, we summarized research progress of the relationship between the structural protein of Newcastle disease virus and virulence, anti-tumor and autophagy of Newcastle disease.
ABSTRACT
Objective To study the gene therapy of metastatic prostate cancer. Methods we investigated the ability of adenoviral vectors expressing cytokines IL-12 and IL-2 to induce regression of tumor in C57BL/6 mice models(n=66) of prostate cancer. Results Adenoviral vectors can express cytokines IL-12 and IL-2 proteins effectively. Only 20%(2/10) of mice inoculated with RM-1 cells engineered AdmIL-12 and AdhIL-2 developed smaller and delayed tumors ( P