ABSTRACT
To systematically assess the efficacy and safety of Jinqi Jiangtang Tablets for patients with insulin resistance in type 2 diabetes, literatures were retrieved in 7 databases: PubMed, EMbase, Cochrane Library, Chinese National Knowledge Infrastructure(CNKI), WanFang database, Chinese BioMedical Database(CBM), VIP Chinese Science and Technique Journals Database, from the date of its inception up to November 2018. Review Manager 5.3 software was used for risk bias assessment, data synthesis and subgroup analysis. Begg's and Egger's tests were performed for assessing symmetries of funnel plot by software Stata 14.0. GRADE system was used to assess the quality of evidence. A total of 10 trials involving 797 participants were eligible. Compared with Western medicine alone, Jinqi Jiangtang Tablets showed a statistical significance in FBG(WMD=-0.63, 95%CI[-1.00,-0.26]). Jinqi Jiangtang Tablets showed a significant decrease in 2 h BG combined with Western medicine compared with Western medicine alone(WMD=-1.46, 95%CI[-1.71,-1.21], P<0.000 01). Jinqi Jiangtang Tablets combined with Western medicine showed a significant decrease in HbA1 c(WMD=-0.75, 95%CI[-0.97,-0.53], P<0.000 01), FINS(WMD=-0.65, 95%CI[-0.80,-0.50], P<0.000 01), 2 h INS(SMD=-1.67, 95%CI[-2.26,-1.09], P<0.000 01) and HOMA-IR(WMD=-1.22, 95%CI[-1.67,-0.76], P<0.000 01). Jinqi Jiangtang Tablets combined with Western medicine was beneficial for ISI(WMD=1.00, 95%CI[0.84, 1.17], P<0.000 01). Egger's and Begg's test showed no publication bias(P=0.379). Sensitivity analysis showed no impact on the overall results. The GRADE quality of the evidence was low. Despite of the apparently positive results, we cannot draw a rational conclusion that Jinqi Jiangtang Tablets has a positive effect in patients with IR, because of the low evidence grade.
Subject(s)
Humans , Diabetes Mellitus, Type 2/drug therapy , Drugs, Chinese Herbal/therapeutic use , Insulin Resistance , TabletsABSTRACT
Objective: To carry out comparative study on energy respond characteristics of 4 kinds of medical diagnostic X-ray dosimeters that included general new imported equipment and domestic equipment.Methods: In the standard radiation field of secondary standard dosimetry laboratory(SSDL)of IAEA,substitution method was adopted to complete contrast measurement of 10 kinds of X-ray diagnosis radiations which voltage were 60-150 kV,tube current were 10 mA and 2.5 mmAl was used as filterable addition.Results: The results of energy respond performances of domestic RD-98 diagnosis dosimeter and imported dosimeter indicated that all of these responses of different energy to dose were within ±5％when X-ray range was 6-150 kV.Conclusion: The energy response characteristics of 4 kinds of new diagnosis X-ray dosimeter were better,and the response of different energy to dose conforms to the requirement of IEC in diagnosis dosimeters of semiconductor detector and air ionization chamber.