Associated risk factors of peritoneal metastasis in colorectal cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To investigate risk factors associated with peritoneal metastasis in colorectal cancer.</p><p><b>METHODS</b>Clinicopathological data of 873 patients with colorectal cancer treated at the Nanfang Hospital of Southern Medical University from January 2003 to December 2008 were retrospectively analyzed. The associations between peritoneal metastasis and clinicopathological factors were evaluated by univariate analysis including independent-samples t test and χ(2) test, and multivariable logistic regression analysis.</p><p><b>RESULTS</b>Univariate analysis showed that age(P=0.032), tumor size(P=0.001), tumor differentiation(P=0.008), depth of bowel wall invasion(P=0.000), lymph node metastasis(P=0.000), serum carcinoembryonic antigen (CEA) level(P=0.003), and serum carbohydrate antigen 19-9(CA19-9) level(P=0.009) were associated with peritoneal metastasis. On multivariable logistic regression analysis, depth of bowel wall invasion, lymph node metastasis, serum CEA level and CA19-9 level remained as significant risk factors(all P<0.05).</p><p><b>CONCLUSION</b>Depth of bowel wall invasion, lymph node metastasis, serum CEA level, and CA19-9 level are risk factors for peritoneal metastasis in colorectal cancer.</p>

Construction and application of evaluation system of laparoscopic colorectal surgery based on clinical data mining / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To construct a clinical database for laparoscopic colorectal surgery in Chinese population using computerized technique.</p><p><b>METHODS</b>A clinical database system was constructed and used in multi-/single-center studies on laparoscopic colorectal surgery.</p><p><b>RESULTS</b>The data of more than 1200 cases in the Nanfang Hospital during the past year were collected retrospectively. The database was used as the platform for "Southern China Laparoscopic Colorectal Surgery Study Group (SCLCSG)" and was used in the first stage of the clinical research of "Multicenter retrospective study of laparoscopic and open procedure for colorectal cancer" among 11 hospitals in Southern China. In order to test the system, the database was also used in "comparative study on oncologic results of laparoscopic versus open radical resection for rectal carcinoma".</p><p><b>CONCLUSIONS</b>The evaluation system is reliable and efficient. This system has established a clinical database for laparoscopic colorectal cancer surgery and can be widely applied for the clinical research for colorectal cancer.</p>