ABSTRACT
Objective To investigate the effect of single use and 1:1 combination use of rhubarb water extract and ethanol extract on blood fat in experimental hyperlipidemia mice.Methods Kunming male mice weighing 20-25 g were selected,given dif-ferent methods of gavage and divided into the control group(Con),model group(Mod),test 1 group(Rhe1,water extract),test 2 group(Rhe2,ethanol extract),test 3 group(water extract and ethanol extract 1:1 compatibility group).The levels of serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in each group were detected on 28 d after experiment.Results The TG and LDL-C levels in the test 1 group were lower than those in the model group(P<0.05),the HDL-C level was higher than that in the model group(P<0.05);the levels of TC,TG and LDL-C in the test 2 group were lower than those in the model group,the HDL-C level was higher than that in the model group(P>0.05);compared with the test 1 group,the levels of TG and LDL-C in the test 2 group were decreased(P<0.05);compared with the test 2 group and test 1 group,the levels of TC,TG and LDL-C in the test 3 group were decreased and the HDL-C level was in-creased(P<0.05).Conclusion Using ethanol for extracting rhubarb has better effect for reducing blood fat.