ABSTRACT
Voltage-gated sodium channels (VGSCs) are heteromeric protein complexes containing one core subunit α and one or more auxiliary subunit β. VGSCs are widely expressed in various forms of tumor cells and tissues. Importantly, subunit α can regulate the invasive capacity of tumor cells, and subunit β is related to the adhesion and migration capacities of tumor cells. The function of subunit β in different types of tumor is different. Emerging studies have revealed that VGSCs have certain effects on tumor invasion and metastasis, which indicates that VGSCs may become the target for tumor diagnosis and targeted therapy. Therefore, this paper summarizes the effects of VGSCs on tumor invasion and migration, as well as the research progress in VGSCs used as tumor therapeutic target.
ABSTRACT
Objective:To explore the preventive function for sweating gustatory syndrome and esthetic effect of restoring parotid gland area defect by using platysma flap. Methods: Nine patients who underwent parotidectomy and restored parotid gland area defect with platysma flap were analyzed retrospectively in this study. Observed whether there was an incidence of subjective sweating gustatory syndrome and introcession in the operation region. Results: There was no incidence of subjective sweating gustatory syndrome. Moreover, introcession in the operation region was not obvious. Conclusion: Restoring parotid defects with platysma flap can reduce introcession in the operation region. Application of platysma flap as an interpositional barrier between the skin flap and the parotid bed after parotidectomy can reduce the incidence of sweating gustatory syndrome.