ABSTRACT
Objective:To evaluate the effectiveness and safety of morpholinidazole in senile suppurative appendicitis during the perioperative period.Methods:A randomized, double-blind, controlled study was used to prospectively analyze 65 senile suppurative appendicitis patients admitted to our hospital from Dec 2017 to Dec 2018. There were 32 cases in the ornidazole group and 33 cases in the morpholinidazole group. The clinical cure rate, the incidence of serious complications, the incidence of wound infection, and the clearance rate of anaerobic bacteria were evaluated 5 days after the administration in the two groups of patients.Results:After treatment, the CRP, PCT, and WBC of the morpholinidazole group were significantly lower than those of the ornidazole group ( P<0.05). The anaerobic clearance rate and the incidence of serious complications were not statistically different in between the 2 groups ( P>0.05). The complications of intraperitoneal infection in the morpholinidazole group were lower than those of the ornidazole group ( P=0.048), The clinical cure rate was also significantly higher than the ornidazole group ( P=0.041). Conclusions:The use of morpholinidazole in elderly patients with suppurative appendicitis during the perioperative period is effective and safe.