ABSTRACT
<p><b>OBJECTIVE</b>To investigate the onset time and efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in children with house dust mites (HDM)-induced allergic rhinitis (AR).</p><p><b>METHODS</b>One hundred and forty three children with perennial moderate to severe HDM-induced AR were treated by SLIT with standardized Dermatophagoides farinae extract. One hundred children who finally completed two years treatment were divided into two groups according to the age: younger children group (aged 4-8 years, n = 52) and older children group (aged 9-14 years, n = 48). Respectively, Each children was assessed before and after 1st, 2nd, 3rd, 6th, 12th, 24th months of the treatment. Total nasal symptom score (TNSS), total medication score (TMS) and visual analogue scale (VAS) were evaluated at each visit. All clinical data were analyzed retrospectively with the SPSS 19.0 software.</p><p><b>RESULTS</b>TNSS, TMS and VAS of two groups decreased significantly after three months of the treatment compared with before (younger children group: Z value was -3.843, -3.534, -3.940, older children group: Z value was -3.938, -3.405, -3.953, all P < 0.05). TNSS and VAS of younger children group decreased significantly after two months of the treatment compared with before (6.4 ± 1.6, 5.3 ± 1.4 vs 8.6 ± 1.2, 7.9 ± 1.6, Z value was -3.843, -3.940, both P < 0.05). Five children (5%) experienced local adverse events and 2 children (2%) experienced mild systemic adverse events. No severe adverse events happened during the treatment.</p><p><b>CONCLUSIONS</b>SLIT with Dermatophagoides farinae drops is an efficient and safe treatment for children with HDM-induced AR. Its onset of action can be observed as early as 3 months after treatment.</p>
Subject(s)
Adolescent , Animals , Child , Child, Preschool , Humans , Administration, Sublingual , Allergens , Antigens, Dermatophagoides , Dermatophagoides farinae , Retrospective Studies , Rhinitis, Allergic, Perennial , Drug Therapy , Software , Sublingual Immunotherapy , Treatment OutcomeABSTRACT
OBJECTIVE@#To analysis the relationship between nasal septal deviation and the bulbous type concha bullosa(CB).@*METHOD@#Analysis the paranasal sinus coronal plane CT scans of 972 patients,observe the incidence of nasal septal deviation and bulbous type concha bullosa and classify them into upper septal deviation and lower septal deviation. Measure the septal deviation angle and transverse diameter of the bulbous type concha bullosa, and a nalysis the relationship between nasal septal deviation and the bulbous type concha bullosa.@*RESULT@#The incidences of bulbous type concha bullosa was 17.03% of 182 patients with nasal septal deviation and was 14.05% of 790 patients without nasal septal deviation. There was no statistically difference between them(P > 0.05). The incidences of bulbous type concha bullosa were 33.33% and 9.02% of the patients with upper septal deviation and lower septal deviation, and the difference was statistical (P 0.05).@*CONCLUSION@#There was a significant relationship between upper nasal septal devia tion and bulbous type concha bullosa, especially finding bulbous type concha bullosa in concave sides of nasal sep turn. But there was no significant relationship between the septal deviation angle and the size of the bulbous type concha bullosa.
Subject(s)
Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Young Adult , Nasal Septum , Congenital Abnormalities , Diagnostic Imaging , Tomography, X-Ray Computed , Turbinates , Congenital Abnormalities , Diagnostic ImagingABSTRACT
OBJECTIVE@#To retrospectively analyze the clinical characteristics of the benign paroxysmal positional vertigo (BPPV) secondary to the sudden deafness (SD) and to explore pathogenetic mechanism.@*METHOD@#One hundred and seventy-eight cases of the SD in our department were retrospectively analyzed. They were all treated under the guidance of clinical guidelines.@*RESULT@#(1) In all these patient's with SD, there were 31 cases with BPPV secondary to the SD. There were 26 cases of BPPV of posterior semicircular canal and 5 cases of BPPV of lateral BPPV semicircular canal. All patients with BPPV were diagnosed as the same ears as the SD, including 16 cases on left sides and 15 on right sides. (2) The interval between the onset of SD and BPPV was less than one week in 27 cases, between one week and one month in 3 cases, and between one and three months in 1 case. (3) All patients with BPPV secondary to the SD were cured with Epley maneuver or Barbecue roll maneuver.@*CONCLUSION@#The occurrence of BPPV may follow SD, and the major of BPPV secondary to the SD occurs in the posterior semicircular canal. The canalith repositioning is an effective therapy to the secondary BPPV.