ABSTRACT
Matrix Metalloproteinase-9 [MMP-9] is a proteolytic enzyme, the significance of which in the follicle maturation has been widely studied in non-stimulated animal models and humans. To compare the level of this enzyme in follicular fluid in PCO [polycystic ovary] and non PCO females undergoing intracytoplasmic sperm injection [ICSI]. MMP-9 was measured in the follicular fluid in 20 PCO and 30 non PCO females undergoing ICSI. Total MMP-9 showed no statistically significant difference between the two groups [p=0.145].While, MMP-9 per oocyte showed a statistically significant difference between the two groups, [p=<0.001]. So MMP-9 per oocyte is greater in non PCO group. There is no difference between MMP-9 secretion in follicular fluid in PCO and non PCO females undergoing ICSI