Study of the possible effects of butorphanol or nalbuphene on ferrokinetic parameters in the rabbit

This work is a trial to clarify the effect of 2 opioid agonist antagonist on different ferrokinetic parameters. The drugs, butorphanol [Stadol] and nalbuphene [Nubain], are easily collected from market, but still their full safety is not sure. Butorphanol induced insignificant changes on serum iron, total iron binding capacity and% saturation of transferrin, and also, no significant changes on red cell count and indices. On the other hand, nalbuphene induced significant changes of the studied parameters. Hence, it was concluded that the second tested drug is less safer from ferrokinetic point of view and may produce iron deficiency anemia

Study of the possible effect of butorphanol or nalbuphene on some hepatorenal functions in the rabbit

Thirty male rabbits were used in this study, they were divided equally to 3 groups, to investigate the effect of repeated daily intramuscular administration of butorphanol or nalbuphene for 4 weeks on some hepatorenal functions. Each drug belonged to the narcotic analgesic group, commonly used; however, their real effect on some body physiological functions still unclear. This study indicated that both drugs induced a severe degree of hepatorenal injury. These actions were evident by increased tremendously aspartate aminotransferase, alanine aminotransferase, serum alkaline phosphatase, serum albumin, blood urea and serum creatinine. Also, the total serum proteins have been reduced. These effects announce that the easy common use of such drugs should be revised; also investigation of the hepatorenal functions should be done before their use

Comparative study between the effects of digitoxin versus digoxin on ferrokinetics

Nineteen male rabbits were included in the present study and classified into three groups to study the effect of repeated oral daily administration of digitoxin [10 mug/kg body wt.] or digoxin [50 mug/kg body wt.] for four weeks on some liver functions [SGPT, SGOT, total serum bilirubin, total serum proteins, serum alkaline phosphatase and prothrombin activity], ferrokinetic parameters [basal plasma iron, post absorption plasma iron tolerance curve, TIBC, UIBC and percent saturation of transferrin], hematological parameters [red cell count, hemoglobin concentration, hematocrit value and red cell indices] and histochemical parameters [iron contents and peroxidase enzyme activity in both the liver and kidney]. The results showed that digoxin produced significant decrease of basal plasma iron, post absorption curve and percentage of saturation of transferrin with significant increase of UIBC. Digoxin produced also mild reduction of iron contents and peroxidase enzyme activity in both the liver and kidney. Digitoxin produced insignificant changes in all the studied parameters. The findings of the present study may suggest that oral administration of digoxin interferes with some ferrokinetics, mainly the intestinal absorption of iron. The effect of digoxin on ferrokinetics seems to affect the cellular iron containing enzymes. The addition of iron therapy was recommended, whenever possible, to patients receiving digoxin for a long time