Four Cases with Side Effects caused by Shakuyaku-kanzo-to / 日本東洋医学雑誌

Four cases which showed side effects caused by Syakuyaku-kanzo-to were reported. All the patients were women over 60 years old with “Chukan-sho” or “Kyo-sho”.<br>Hypopotassemia was noted in all 4 cases, muscular weakness in 3 and edema in 1. Treatment of side effects involved discontinuing administration of Syakuyaku-kanzo-to in all cases. Potassium administration was additionally required in 2 cases of severe hypopotassemia. Muscular weakness and edema disappeared with recovery from hypopotassemia.<br>Taking past reports into consideration, it is suggested that, in older woman, “Kyo-sho” and “Suidoku” are important risk factors for pseudoaldosteronism caused by Syakuyaku-kanzo-to.