ABSTRACT
Objective:To study the protective effect of Mongolian medicine Bateri-7 on radiation-induced intestinal injury in mice.Methods:C57BL/6J male mice were randomly divided into control group, irradiation group and irradiation plus drug administration group, with 10 or 15 mice in each group. For irradiation group, the mice were given a single dose of 12 Gy 60Co γ-rays with total body irradiation. For drug treatment, the mice were gavaged with Bateri-7 (530 mg/kg) 7 d before irradiation until 3 d after IR. At 6 h and 24 h after irradiation, the Tunel positive cells in intestine were detected immunohistochemically. At 3.5 d after irradiation, the structure of intestinal villi was observed by HE staining, and the BrdU and Ki67 positive cells were detected immunohistochemically. The expression levels of IL-6, TNF-α and Cxcl-5 were detected by qPCR. The FITC-dextran in peripheral blood was also determined. Results:The survival of irradiated mice was significantly increased by Bateri-7 ( χ2= 5.84, P < 0.05), but there was no significant difference in weight between two groups ( P > 0.05). The villi length of small intestine in the irradiation plus drug group was significantly longer than that in the irradiation group ( t = 20.24, P < 0.05), and there was no significant difference in the depth of intestinal crypt between two groups ( P > 0.05). At 6 and 24 h after irradiation, the number of Tunel positive cells in intestinal crypts in the irradiation plus drug group was significantly reduced in comparison with the irradiation group ( t = 3.52, 2.90, P < 0.05). At 3.5 d after irradiation, the level of FITC-dextran in serum and the expressions of IL-6, TNF-α and Cxcl-5 in small intestine of mice in the irradiation plus drug group were significantly lower than those in the irradiation group, respectively( t = 6.92, 7.01, 7.18, 13.16, P < 0.05). The number of BrdU and Ki67 positive cells in the crypt of mice in the irradiation plus drug group was higher than that of the irradiation group ( t = 3.91, 2.57, P < 0.05). Conclusions:Mongolian medicine Bateri-7 can effectively alleviate irradiation-induced intestinal injury of mice, which may have a good preventive and therapeutic effect on radiation enteritis.
ABSTRACT
ObjectiveTo explore the personality traits on higher vocational students with mathematics learning difficulties(MD).MethodsAll students of three grades in their first year were divided into MD students ( n =486) and outstanding students ( n =407 ) according to their final math scores.Cattell's 16 PF Questionnaires was used to assess the personality.ResultsStudents with MD got significantly higher records in personality factors of aggressiveness (6.59 ± 1.94 ),excitability ( 7.29 ± 2.24 ),sensitivity ( 5.85 ± 1.98 ),suspicion ( 3.51 ±2.03 ),fantasy(5.76 ± 1.86 ),urbane ( 5.81 ± 1.75 ),tense ( 5.63 ± 2.05 ),adapting and anxiety type ( 4.49 ±2.23 ),introverted and expert-oriented type(7.59 ± 2.43 ),and cowardice and decisive type ( 5.04 ± 1.62 ) than outstanding students(P＜0.05) ;however,they got lower records in personality factors of steadiness(5.89 ±2.19),perseverance (4.41 ± 1.98 ),independence ( 3.74 ± 1.77 ),emotional with unruffled alert type ( 5.51 ± 1.81 ),professional achievements (52.72 ± 10.66),growth ability in new environments ( 18.78 ± 3.91 ) (P ＜ 0.05 ).ConclusionHigher vocational students with MD have sensitive,suspicious,nervous,anxious,exoscopic,excited,fantasy personalities,lacking self-control,elasticity,carefulness and constancy.