ABSTRACT
Trisomy 18, called Edward syndrome, occurs in about 3500-8000 births. It is much more common at conception, with about 95% of cases resulting in spontaneous abortion or stillbirth. Postnatal survival is poor, with the majority of patients dying in early infancy. Characteristic findings include cardiac malformations, mental retardation, growth retardation, a prominent occiput, micrognathia, clenched hands, and rocker-bottom feet, omphalocele. The prenatal sonographic findings of our case include delayed growth, omphalocele, wrist joint fixation, choroid plexus cyst, hydramnios and postnatal gross findings include growth retardation, omphalocele, wirst joint fixation, absence of radius, syndactyly, focal absence of phalanges and flexion deformities of fingers and toes. We report a case of prenatally diagnosed Edward syndrome, which is confirmed by chromosome analysis, with brief review of related literatures.
Subject(s)
Female , Humans , Pregnancy , Abortion, Spontaneous , Choroid Plexus , Congenital Abnormalities , Fertilization , Fingers , Foot , Hand , Hernia, Umbilical , Intellectual Disability , Joints , Parturition , Polyhydramnios , Radius , Stillbirth , Syndactyly , Toes , Trisomy , Ultrasonography , Ultrasonography, Prenatal , Wrist JointABSTRACT
No abstract available.
ABSTRACT
Obstetrical hemorrhage is one of the deadly triad, along with hypertensive disorder in pregnancy and infection. Postpartum hemorrhage is the major cause of obstetrical hemorrhage. Uterine atony is the most common cause of postpartum hemorrhage, and resulted from poor uterine contraction after delivery of the fetus and placenta. Initial management to control postpartum uterine atonic bleeding is based on the use of uterotonics such as well known oxytocin and ergot preparations together with uterine massage. Prostaglandin E2 analogue, sulprostone can be used next when these agents are failed to produce uterine contraction. The woman unresponsive to non-surgical managements requires surgical interventions including emergency hysterectomy. Recently prostaglandin E1 analogue, misoprostol, has been known to elicit potent uterine contraction and cervical ripening after oral, vaginal or rectal administration. We have experienced two cases of postpartum uterine atonic bleedings which were unresponsive to oxytocin, ergot, or prostaglandin E2, but were successfully controlled by rectal administration of misoprostols.
Subject(s)
Female , Humans , Pregnancy , Administration, Rectal , Alprostadil , Cervical Ripening , Dinoprostone , Emergencies , Fetus , Hemorrhage , Hysterectomy , Massage , Misoprostol , Oxytocin , Placenta , Postpartum Hemorrhage , Postpartum Period , Uterine Contraction , Uterine InertiaABSTRACT
No abstract available.