ABSTRACT
Toxoplasma gondii is a kind of worldwide obligate intracellular parasitic protozoa,which can live in almost all nucleated cells besides red blood cells and cause zoonosis.Toxoplasma gondii is mainly transmitted by the fecal-oral route;damaged skin,mucous membrane and the placenta are the secondary pathway.After infection,the parasite need to invade host cells and formate parasitophorous vacuole to complete reproductive cycle,while many studies have shown that actin binding protein profilin of Toxoplasma gondii(TgPRF) play important roles in regulating actin polymerization and invading host cells.At the same time,TgPRF can be used as a dominant antigen to induce host immune response,especially innate immunity through Toll like receptor (TLR).In this paper,the structural characteristics of TgPRF and its roles in the invasion of the host and inducing the host immune responses were reviewed,which would provide profound understanding of Toxoplasma gondii pathogenic mechanism and a reference for immune prevention.