ABSTRACT
Solid dispersions provide an effective technical method for improving solubility and bioavailability of insoluble drugs. From its discovery to the present 60 years, 26 drug formulations have been approved by FDA. Moreover, the preparation technology of solid dispersion system has been continuously innovated and developed, such as electrospinning method, supercritical fluid method, spray freeze-drying technology and so on. In this paper, the development process of solid dispersion technology and carrier is reviewed, and the development of solid dispersion technology and carrier is summarized, and the existing problems are analyzed and prospected. It is expected to provide the reference for the research and development of drug solid dispersion.
ABSTRACT
The strain of DG7 isolated from the oilwater sample in DAGANG oilfield could produce surfactant ?acids and gas in the culture medium in which the diesel was sole carbon source .The strain was Gram-negative, motive, rod and growed facultatively in the 0 to 18.5% NaCl. Based on its characters, the strain was identified as a member of the genus Aeromonas, but there were some differences between this strain and the described species of this genus in some biochemical features, suggesting that it could be a new species of the genus.