ABSTRACT
Objective: To investigate the associations of the mutation status of epidermal growth factor receptor (EGFR) with the factors including gender, age, smoking status, family history and histological type in patients with non-small cell lung cancer (NSCLC). Methods: From February 2008 to May 2012, 538 consecutive NSCLC patients went through the clinical testing for EGFR mutations in Shanghai Pulmonary Hospital were included in this study. Amplification refractory mutation system (ARMS) method was used to detect EGFR mutation status. The relationships between EGFR mutation and potential related factors were evaluated by using Logistic regression model. Results: The activating mutation of EGFR was found in 220 patients. EGFR mutation was more frequently detected in females (P < 0.001), patients with adenocarcinoma (P < 0.001), never-smokers (P < 0.001) and patients with family history of cancer (P = 0.031). Multivariate analysis revealed that pathologic type [odds ratio (OR) = 0.035)], smoking status (OR = 0.005) and family history of cancer (OR = 0.027) were independent predictive factors of EGFR mutation. Conclusion: The factors of pathologic type, smoking status and family history of cancer are independent predictive factors of EGFR mutation. Copyright © 2014 by TUMOR.