ABSTRACT
<p><b>OBJECTIVE</b>To observe the infection of the high risk human papillomavirus (HPV) in the specimen of the small cell neuroendocrine carcinoma of the uterine cervix (SCNEC).</p><p><b>METHODS</b>We extracted the nucleic acids in the formalin-fixed and paraffin-embedded specimen from a 33-year-old patient diagnosed as small cell neuroendocrine carcinoma of uterine cervix and detected the HPV genotype with the nested PCR.</p><p><b>RESULTS</b>We identified HPV18, a high-risk genotype, in the specimen.</p><p><b>CONCLUSION</b>The HPV detection with the nested PCR was available for identification of the HPV genotype(s) in the paraffin-embedded specimens of small cell neuroendocrine carcinoma of the uterine cervix with a high accuracy and sensitivity.</p>
Subject(s)
Adult , Female , Humans , Base Sequence , Carcinoma, Neuroendocrine , Virology , Carcinoma, Small Cell , Virology , Human papillomavirus 18 , Genetics , Molecular Sequence Data , Polymerase Chain Reaction , Uterine Cervical Neoplasms , VirologyABSTRACT
<p><b>OBJECTIVE</b>To investigate the infection of the high risk human papillomavirus (HPV) in the specimen of the clear cell carcinoma of the cervix.</p><p><b>METHODS</b>We extracted the nucleic acids in the formalin-fixed and paraffin-embedded specimens from a 37-year-old patient with clear cell carcinoma of the cervix and detected the HPV genotype with the nested PCR.</p><p><b>RESULTS</b>We identified HPV18, a high-risk genotype, in the specimens.</p><p><b>CONCLUSION</b>The HPV detection with the nested PCR was available for identification of the HPV genotype(s) in the paraffin-embedded specimens of clear cell carcinoma of the cervix (CCCC) with a high accuracy and sensitivity.</p>