ABSTRACT
Objective To assess whether aortic valve calcification (AVC) and mitral annual calcification (MAC) is independent predictors for coronary artery disease (CAD).Methods Coronary CT angiography(CCTA) data in a total of 263 patients were included in this study,including 30 patients with MAC, 82 patients with AVC and 31 patients with MAC+AVC;meanwhile other 120 patients without valvular calcification were regarded as a control group.Five indicators were used to evaluate the extent and severity of CAD, namely, the prevalence of coronary plaque, multi-coronary vessels lesions, degrees of coronary artery narrowing, incidence of moderate to severe coronary artery calcification score and mean number of affected coronary artery segments.The correlations of MAC,AVC,MAC+AVC with CAD were analyzed by Logistic regression analysis.Results The presence and severity of CAD were significantly greater in patients with MAC, AVC and MAC+AVC than those in control group.After adjustment for CAD conventional risk factors,Logistic regression analysis revealed that AVC,MAC and MAC+AVC were independently associated with the presence and severity of CAD.Conclusion AVC and MAC are independent predictors for CAD and often predict the more presence and greater severity of CAD.