Extended resection for pancreatic carcinoma / 中国实用外科杂志

ObjectiveIn order to enhance the curative resectability rate of pancreatic carcinoma. MethodsSixteen consecutive patients received an extended resection, which is referred to systemic dissection of regional lymph nodes and combined resection of the diseased PV/SMV based on traditional Whipple operation or the distal pancreatectomy. ResultsMean operation time was 8.5 hours. Mean intraoperative blood infusion was 1250mL. The procedure was considered curative in 11 (68.8 % ) and palliative in the other five. Postoperative complications occurred in 7 (43.8% ). Perioperative death occurred in one patient(6.25% ). Median length of hospital stay was 35 days. In nine patients undergoing curative resection,two cases survived for 1/2～1 year, six patients survived for 1～2 year and another patient has survived for more than 32 months without evidence of recurrence. ConclusionExtended resection for pancreatic cancer is technically feasible and two- third of pancreatic carcinoma invading PV/SMV alone can be expected to obtain curative resecetion.

Mutation of the transforming growth factor-? typeⅡ receptor gene in sporadic colorectal cancers with microsatellite instability / 中国病理生理杂志

AIM: To determine the relationship between the mutation of the RII gene and RER status in the tumorigenesis of sporadic colorectal cancer. METHODS: We screened RER status and mutation of the RII gene from 50 sporadic colorectal cancers (19 in the proximal colon, 31 in the distal colorectum). RESULTS: RER was found in 13 cases (8 in the proximal colon, 5 in the distal colorectum), and 5 of them showed mutations of the RII gene. All 5 cancers carrying a TGF-? RII gene mutation showed RER+, but there wasn't any mutation of RII gene in RER(-) cases. Four of 5 RII mutation were located at the cecum. CONCLUSION: These data indicate that the TGF-? RII gene is a major target of microsatellite instability and mutation of the RII gene play an important role in carcinogenesis of sporadic colorectal cancer with microsatellite instability, especially at the cecum. [

Clinical analysis of 37 cases of gallbladder carcinoma / 临床外科杂志

Objective In order to make clear the clinical characteristics of gallbladder carcinoma.Method 37 cases of gallbladder carcinoma treated in Xinhua hospital have been analyed in recent 5 years.Result The higher incidence was in the elderly and the ratio between femal and male is 2 1 to 1.Clinical symptoms include right upper abdominal pain,nausea,fever,jaundice and abdominal mass.With gallstones is about 81 1%.Conclusion BUS and CT are common diagnostic methods.BUS is more reliable in early case,but CT in late case.The type of operation and the result of treatment are dependent on the pathologic stage and grade.