ABSTRACT
The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism. The content of the trace elements [Zn, Cu, Mn, and Se] in the serum of patients was determined and compared to that of normal subjects. Ninety eight [98] patients with hyperthyroidism were participated in this study and fifty normal healthy persons were taken as control. Serum zinc and copper were determined using flame atomic absorption spectrophotometer while serum manganese and selenium were estimated using flameless atomic absorption spectrophotometer technique. The study showed that serum zinc and selenium level of hyperthyroidism patients were significantly lower [p<0.05] than the level in normal subjects. While a significant increase in serum copper level was demonstrated in patients as compared with that of the normal subjects. The results showed no significant difference between the groups [p>0.05] in serum manganese. The present study confirmed a significant changes in the levels of serum Zn, Cu, and Se in hyperthyroidism patients and these changes may be related to pathophysiology of thyroid disease
ABSTRACT
Limited data are available with regard to the relation between maternal and fetal serum lipid and lipoprotein levels and the mode of delivery. The aim of this study is to evaluate the effect of mode of delivery on the levels of serum lipid and lipoprotein of mothers and their umbilical cords. This study is consisted of fourty-nine pregnant women delivered by elective caesarean [CS] and seventy-five age-and gestational age-matched pregnant women who delivered by normal vaginal delivery[NVD].Serum lipid profile parameters including; total cholesterol [Tch], triglyceride [TG], high density lipoprotein-cholesterol [HDL-C] and low density lipoprotem-cholesterol [LDL-C] were measured in the serum of these two groups of pregnant women as well as in the serum of their umbilical cords. The mean [ +/- SEM] values of serum Tch, TG, and LDL-C were significantly higher in pregnant women who delivered by NVD when compared with those of pregnant women delivered by CS[all P< 0.001].With regard to serum HDL-C mean value there was no significant difference between these two groups. Similarily,the mean [ +/- SEM] values of serum Tch, TG, LDL-C were significantly increased in umbilical cord of NVD mothers in comparison with values obtained in umbilical cord of CS mothers[all P< 0.001]. There was also a significant positive relationship between mothers and umbilical cord serum Teh levels in NVD group[r=0.339, P< 0.001]. This study revealed that the mode of delivery, in particular, NVD changes significantly the concentrations of lipid parameters mainly Tch, TG, and LDL-C. Such changes require an important attention postpartumly for such mothers with respect to biochemical investigation, particularly lipid parameters