ABSTRACT
@#<b>Objective</b> To analyze the abnormality of radiation damage sensitive indices in radiation workers after operation of a third-generation nuclear power plant in Guangdong Province, China, and to provide a basis for promoting the occupational health management of radiation workers. <b>Methods</b> A two-way cohort study (2019—2021) was conducted to compare the radiation sensitive indices of occupational health examination in the exposed group (453 subjects) and the control group (160 subjects). <b>Results</b> In 2021, the free triiodothyronine (FT3) level of the exposed group was significantly higher than that of the control group [(5.57 ± 0.56) pmol/L <i>vs</i> (5.42 ± 0.60) pmol/L, <i> t</i> = 0.59, <i>P</i> < 0.05]. From 2019 to 2021, the exposed group showed significant changes in the average levels of platelet, hemoglobin, FT3, free thyroxine (FT4), and thyroid-stimulating hormone (<i>P</i> < 0.05); FT3 and FT4 first increased and then decreased, while TSH decreased continuously. <b>Conclusion</b> Long-term exposure to low-dose ionizing radiation from nuclear power plants can affect the platelet, hemoglobin, FT3, FT4, and thyroid-stimulating hormone of radiation workers, and the effect is relatively prominent on thyroid function by causing a tendency to hypothyroidism.
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Objective To determine the current prevalence and risk factors of metabolic syndrome (MS) among adult residents in Chinese developed areas.Methods The clinical data of 6614 adult residents,including 4051 women,from Guangdong and Jiangsu provinces from China Diabetes and Metabolic Disorders Study (2007-2008) were analyzed.Age and sex standardized prevalences of MS were calculated according to the criteria of Chinese Diabetes Society (CDS),US National Cholesterol Education Program Adult Treatment Panel Ⅲ (ATP Ⅲ),International Diabetes Federation (IDF) and Joint Interim Statement (JIS),respectively.Logistic regression analysis was performed to identify the risk factors of MS.Results Age and sex standardized prevalences of MS were 17.88％ (CDS),28.50％ (ATP Ⅲ),21.99％ (IDF) and 31.50％ (JIS),respectively.The prevalences of residents with at least one metabolic abnormality were 67.86％ (CDS) 79.56％ (ATP Ⅲ),79.62％ (IDF) and 80.74％ (JIS),respectively.MS was more common in female than in male by the ATPⅢ and IDF criterion (ATPⅢ:30.63％ vs 26.45％,P ＜0.01 ; IDF:26.04％ vs 17.91％,P ＜ 0.01),while the prevalence was higher in male by CDS criteria (15.94％ vs 19.87％,P ＜0.01).There was no significant difference in the MS prevalence between the rural and the urban residents.Kappa test showed ATP Ⅲ and JIS criteria were most homogenous (κ =0.95,P ＜ 0.01).The risk factors for MS by the logistic regression model were male,older age,lower degree of education,family history of hypertension and obesity,drinker as well as uncontrolled diet.Conclusion The prevalence of MS is high in the adult residents of Chinese developed areas (Guangdong and Jiangsu provinces),whatever diagnostic criterion was used.Effective measures should be taken to control the modifiable MS risk factors.
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The neurogenic pulmonary edema (NPE) was produced consistently in rabbits by raising intracranial pressure (ICP) with an infusion of anticoagulat rabbit blood into subarachnoid space of the bilateral parietal regions. When ICP increased from 60mmHg to 140 mmHg, There was a rapid decrease in blood flow volume of the bilateral internal carotid arteries (ICABFV). At the same time, the frequency of cervical sympathetic discharge and the concentrations of plasma noradrenaline and adrenaline increased acutly accompanied by a rapid elevation of systemic arterial pressure (SAP). There was a decline in SAP and a further decrease in ICABFV and the animal died as ICP was sustained at 140mmHg for 5-20min. Autopsy revealed severe hemorrhagic pulmonary edema and the left ventricular and atrial enlargement. In the period of ICP rising, the NPE was prevented if SAP was kept at the baseline levels by withdrawing blood from femoral artery, The results suggest that decreased cerebral blood supply due to ICP rising is responsible for the massive sympathetic discharge and catecholamine release which contribute to SAP elevtion and left ventricular overload, the NPE is mediated by hemodynamic mechanism.
ABSTRACT
The plasma histamine concentration was elevated from the control level of 1.16? 0.28ng/ml to 11.42?5.2ng/ml 2-5 min after intravenous injection of Serratia mar-cescens endotoxin,and then declined gradually.The level was still slightly higher than the control 4 h later. The plasma noradrenaline(NA)and adrenaline (Ad) concentrations were increased from the control value of 1.13?0.28ng/ml and 1.05 ?0.32ng/ml to 7.33?1.86ng/ml and 10.04? 3.94ng/ml respectively. Six h later they were still significantly elevated.Arterial blood pressure was reduced to 24.16%of the control level 2-5 min after injection and to 69.2% 6 h later.Both cardiac output and cardiac index were decreased, but the peripheral resistance was increased during endotoxin shock. The significant dilatation of arterioles, venules and capillaries of bulbar conjunctiva microcirculation occurred 1-2 min after endotoxin injection, and the blood flow slowed down at the same time.Five min - six h after endotoxin injection arterioles constricted markedly, but capillaries and venules were still congested and distended.From this study, the interrelationship of some changes in the development of endotoxin shock were discussed.Endotoxin caused the congestion in microcirculatiolelen, reduction of blood returning to the heart and reduced peripheral resistance owing to the histamine released in large amounts. Drastic drop in blood pressure resulted in the increase of NA and Ad release reflexly, which led to the constriction of arterioles, the increase of the peripheral resistance and the restoration of the blood pressure to some extent.Since venules and capillaries were distended and congested,blood pressure and cardiac output still remained at lower level all the time during endotoxin shock.