ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of bile in inducing gastric mucosal injury in rats.</p><p><b>METHODS</b>SD rats were divided into 4 groups, namely bile duct ligation group, duodenogastric reflux (DGR) group, DGR plus bile duct ligation group and normal control group. The pathological changes in the gastric mucosa and tight junction 3 months after gastrojejunostomy were observed and compared with the findings in the normal control rats.</p><p><b>RESULTS</b>Compared with the rats in DGR plus bile duct ligation group, the rats in DGR group showed obvious gastric mucosal hyperemia, foveolar hyperplasia and severely impaired tight junction between the gastric mucosal cells.</p><p><b>CONCLUSION</b>Bile plays an important role in gastric mucosal injury due to DGR.</p>