Clinical application of the disposable circumcision suture device in male circumcision / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the safety and efficiency of the disposable circumcision suture device (DCSD) in the surgical treatment of phimosis and redundant prepuce.</p><p><b>METHODS</b>We randomly assigned 249 outpatients with phimosis or redundant prepuce to be treated with DCSD (n = 129) and by conventional circumcision (CC, n = 120), respectively. Then we compared the safety and efficiency of the two strategies.</p><p><b>RESULTS</b>Comparisons between DCSD and CC showed that the operation time was (4.02 +/- 0.69) vs (30.8 +/- 4.05) min, blood loss was (1.07 +/- 1.29) vs (8.72 +/- 2.15) ml, intraoperative pain score was 0.81 +/- 0.81 vs 2.42 +/- 1.15, 24-hour postoperative pain score was 1.84 +/- 1.02 vs 4.99 +/- 1.36, postoperative complication rate was 13. 95% (18/129) vs 9.17% (11/120), wound healing time was (13.99 +/- 9.06) vs (17.48 +/- 3.49) d, satisfaction with the penile appearance was 98.4% (127/129) vs 95% (109/120), and treatment cost was (2215.62 +/- 17.67) vs (576.47 + 15.58) Y RMB. DCSD exhibited obvious superiority over CC for shorter operation time, less blood loss, milder intraoperative pain, sooner wound healing, and better penile appearance, but it also had a higher rate of postoperative complications (P > 0.05) and involved more treatment cost than the latter (P < 0.05).</p><p><b>CONCLUSION</b>The disposable circumcision suture device affords ideal clinical effects and therefore deserves clinical popularization.</p>

Efficacy and postoperative complication of tension-free vaginal tape-Secur for female stress urinary incontinence / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>As the third-generation tension-free tape for female stress urinary incontinence (SUI), tension-free vaginal tape (TVT)-Secur has decreased the common complications associated with TVT and tension-free vaginal tape-transobturator (TVT-O), such as bladder perforation and obstruction of the bladder outlet; but its efficacy and persistence were still controversial. The aim of this study was to prospectively evaluate and compare the postoperative efficacy and complication at different follow-up time.</p><p><b>METHODS</b>Patients with SUI, who underwent TVT-Secur treatment in two hospitals from October 2008 to October 2009, were selected. By analyzing preoperative and intraoperative data and postoperative complications, the therapeutic effect and satisfaction at different follow-up stages were evaluated.</p><p><b>RESULTS</b>A total of 30 female patients participated in this study. Patients were scheduled for follow-up at the 1st month, 3rd month, 6th month and 12th month, while the cure rate was 83.3% (25 patients), 66.7% (20 patients), 63.3% (19 patients) and 60.0% (18 patients) respectively and the overactive bladder (OAB) symptoms appeared in 11 patients (36.7%), 10 patients (33.3%), 6 patients (20%) and 7 patients (23.3%) respectively.</p><p><b>CONCLUSION</b>With the follow-up time becoming longer, TVT-Secur has a high recurrence rate of SUI, the therapeutic effect from the 3rd month to the 12th month is relatively persistent.</p>

Efficacy of interleukin-10 for experimental autoimmune prostatitis / 中华男科学杂志

<p><b>OBJECTIVE</b>To study the efficacy of interleukin-10 (IL-10) in the treatment of experimental autoimmune prostatitis (EAP) and its effect on the expressions of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1 ) in EAP rat models.</p><p><b>METHODS</b>Thirty Wistar rats were equally and randomly divided into a control, an EAP and an IL-10 group. The controls were treated with normal saline, the EAP models were made by injection of purified prostate protein twice with immune adjuvant, and the IL-10 group included the EAP models subjected to IL-10 intervention. The infiltration of the inflammatory cells of the prostate tissue was detected by HE staining, the ultrastructure of the prostate cells and their surrounding cells observed by electron microscopy, and the levels of TNF-alpha and TGF-beta1 in the three groups determined by semi-quantitative RT-PCR assay.</p><p><b>RESULTS</b>The EAP group showed significantly severer inflammation and higher levels of TNF-alpha and TGF-beta1 in the prostate tissue than the controls (P < 0.05). The IL-10 group exhibited significantly lessened inflammatory infiltration of the prostate tissue and decreased levels of TNF-alpha and TGF-beta as compared with the EAP group (P < 0.05).</p><p><b>CONCLUSION</b>IL-10 could relieve inflammatory infiltration of the prostate tissue and inhibit the expressions of TNF-alpha and TGF-beta1 in EAP rats, which is suggestive of its therapeutic efficacy for autoimmune prostatitis.</p>

Transabdominal ultrasound measurement of intravesical prostatic protrusion helps diagnosis of benign prostatic obstruction / 中华男科学杂志

<p><b>OBJECTIVE</b>To evaluate the measurement of intravesical prostatic protrusion (IPP) by transabdominal ultrasonography (TAUS) in the diagnosis of benign prostatic obstruction (BPO).</p><p><b>METHODS</b>We studied the clinical data of 109 BPH patients referred for lower urinary tract symptoms (LUTS) from April 2005 to December 2006. IPP was measured by TAUS, urodynamic parameters such as Qmax and PdetQmax obtained by urodynamic studies and AG values calculated. The patients were divided into an obstruction and a non-obstruction group according to their AG values.</p><p><b>RESULTS</b>IPP was found statistically different between the obstruction and non-obstruction groups (P<0.001) and positively correlated with the AG value (r=0.729, P=0.001). With the cutoff at IPP > or = 10 mm for the diagnosis of BPO, the sensitivity, specificity and accuracy of the diagnosis were 89.9%, 97.5% and 92.7%, respectively.</p><p><b>CONCLUSION</b>The measurement of IPP by TAUS offers a valuable help for the diagnosis of BPO.</p>

Clinical analysis of postoperative delirium in elderly patients with benign prostatic hyperplasia / 中华男科学杂志

<p><b>OBJECTIVE</b>To study the influential factors leading to postoperative delirium in elderly patients with benign prostatic hyperplasia(BPH).</p><p><b>METHODS</b>For 198 elderly postoperative BPH patients in our hospital, the clinical parameters including age, hypoxemia, postoperative pain, and sleep reduction were investigated, and the data were processed by chi2 test.</p><p><b>RESULTS</b>Of the total number of patients, 13 (6.5%) experienced postoperation delirium. Many factors were significantly correlated with the problem in these elderly BPH patients, such as advanced age (> or =70), postoperative pain and sleep reduction (P < 0.05).</p><p><b>CONCLUSION</b>Advanced age, postoperative pain and sleep problem were important factors for delirium, and therefore postoperative analgesia and good sleep may help to prevent postoperative delirium.</p>

Effect of sildenafil on nocturnal penile tumescence / 中华男科学杂志

<p><b>OBJECTIVE</b>To evaluate the efficacy of sildenafil on nocturnal penile tumescence (NPT).</p><p><b>METHODS</b>Thirty-five patients with erectile dysfunction (ED), 28 cases of organic ED and 7 cases of psychogenic ED, were treated with sildenafil 100 mg before bedtime. The NPT of the patients was observed by using NEVA.</p><p><b>RESULTS</b>Erectile function significantly improved in the 28 cases of organic ED (P < 0.05), but not in the 7 cases of psychogenic ED (P > 0.05).</p><p><b>CONCLUSION</b>Sildenafil can improve NPT of organic ED patients without sexual stimulation.</p>