ABSTRACT
OBJECTIVE@#To assess the association of SLC6A4 gene c.*670T>G polymorphism with the risk for asthma and peripheral blood cytological characteristics among ethnic Zhuang Chinese from Guangxi, China.@*METHODS@#From May 2017 to March 2020, 258 patients diagnosed with asthma and 244 healthy controls were recruited from the Affiliated Hospital of Youjiang Minzhu Medical College and the People's Hospital of Hechi. Genotypes of the c.*670T>G polymorphism were determined by Sanger sequencing. Flow cytometry was used in combination with an electrical impedance method for the counting and classification of peripheral blood cells.@*RESULTS@#Compared with the T allele, the G allele of the c.*670T>G polymorphism was associated with the risk for asthma in the population (OR = 1.54, 95%CI = 1.15-2.06; P = 0.004). Compared with the GT and TT genotypes, homozygous GG genotype also comprised a risk factor (OR = 1.66, 95%CI = 1.16-2.38; P = 0.005). Stratification of the risk factors showed that the homozygous GG genotype has increased the risk of asthma in males and urban residents (P < 0.01). The erythrocyte, hemoglobin and platelet counts of the asthma group were significantly higher than the control group (P < 0.001). The GG, GT and TT genotypes have respectively accounted for 82.35%, 17.65% and 0% of the samples with platelets exceeding the normal value. The overall platelet level of GG genotype was higher than GT+TT genotype (P < 0.05). The significant association was verified by the false positive report probability, and at a prior probability level of 0.1, G vs. T false positive probability was 0.071, and GG vs. GT+TT false positive probability was 0.153.@*CONCLUSION@#The GG genotype of the c.*670T>G polymorphism is associated with the risk for asthma among ethnic Zhuang Chinese from northwest Guangxi. Above finding has also enriched the genotypic data and peripheral blood phenotype for this polymorphism.
Subject(s)
Male , Humans , East Asian People , China , Genotype , Alleles , Asthma/genetics , Serotonin Plasma Membrane Transport ProteinsABSTRACT
This cross-sectional study examined cigarette smoking knowledge, attitudes, and practices among medical students in a southwestern region of China. The subjects included 557 and 223 first and fourth year Chinese medical students, respectively. Comparison data were collected from 74 Japanese and 90 Vietnamese fourth year medical students. The smoking rate among the fourth year medical students in China (7.0%) was significantly higher than among the first year medical students (2.8%), and higher than among the medical students from Vietnam, but lower than the medical students from Japan. The fourth year Chinese students had a more permissive attitude toward cigarette smoking by physicians compared with the first year students, and the lowest knowledge base on cigarette smoking-related diseases among the students from all three countries. Based on a multivariate analysis, the factors associated with cigarette smoking were male gender, having friends who smoked, and exhibiting a permissive attitude toward smoking. Implementations aimed at improving tobacco education and addressing the gender differences and peer influences related to cigarette smoking are needed to improve Chinese medical students’ knowledge and attitudes about cigarette smoking, and to prevent students from starting to smoke cigarettes.
ABSTRACT
BACKGROUND: The middle-school stage is the key period of personality figuring and taking shape.The mentation in this period is filled with a lot of special psychological contradictions and conflicts. Long-term psychological worry will affect the formation of perfect personality.OBJECTIVE: To understand the psychological health status in the middle-school students of Zhuang nationality and the main factors of influence.DESIGN: Randomized cluster sampling and questionnaire investigation based on middle-school students.SETTING: Department of Preventive Medicine, Youjiang Medical College of Nationalities.PARTICIPANTS: 2 000 middle-school students of 34 classes from 3 middle schools in Baise City and Longlin County were selected to attend the investigation with randomized cluster sampling method in November 2003.METHODS: The psychological health statuses of middle-school students were evaluated with symptom checklist (SCL).The list contained 90 items,including 9 factors of psychological symptom such as somatization,compulsion,sensitivity to human relations,anxiety,depression,hostility,dread,paranoia and psychosis.The grading system from 1 to 5 grades was used and the standard of the adult norm of the whole country was refered to:Factor score＜1.8 was normal;Factor score from 1.8 to 2.0 was mild abnormality;Factor score from 2.1 to 3.0 was moderate abnormality;Factor score＞3.0 was severe abnormality. Instructive words were unified.The investigative method and behavior were normalized.The questionnaires were filled in without recording the names and taken back from the spot and then compared with the norm of the whole country.MAIN OUTCOME MEASURES: The evaluated result of psychological health in middle-school students.RESULTS: 2 000 questionnaires were provided and 1 855 were valid after return with the effective rate 92.75%. ①The average scores of each factor of SCL were all higher in the middle-school students of Zhuang nationality than in the norm of the whole country. The significance of difference existed(P=0.000).②The scores of somatization,depression,anxiety,dread and psychosis were all higher in the schoolgirls than in the schoolboys.The significance of difference existed (P=0.000).③Except hostility factor,the scores of other factors were higher in the senior middle-school students than in the junior middle-school students.The difference was statistically significant(P=0.000).④The arranged sequences(from bigness to smallness) of each factor that affected psychological health of middle-school students of Zhuang nationality in Baise were depression,somatization,compulsion,anxiety,sensitivity to human relations,psychosis,paranoia,hostility and dread.The sensitivity to human relations ranked 4th and the anxiety ranked 6th in the schoolboys,but the orders of the 2 factors were just the opposite in the schoolgirls and the orders of other factors were the same in both the schoolboys and the schoolgirls.The first 3 factors all were:depression,somatization, compulsion.CONCLUNSION: The psychological health status was lower in the middle-school students of Zhuang nationality than in the norm of the whole country and the first 3 factors that affected their psychological health were:depression,somatization and compulsion. The levels of psychological health on somatization,depression,anxiety,dread and psychosis were lower in the schoolgirls than in the schoolboys. The psychological problems were more serious in the senior middle-school students than in the junior middleschool students. The levels of psychological health in middle-school students of Zhuang nationality were relatively lower and the psychological education and intervention study should be provided aiming at psychological characteristics of different population.
ABSTRACT
To arouse students’autonomous study,a reform was carried out in experimen- tal teaching of preventive medicine. Taking exploratory experiment as a cut-in point,students were free to choose subjects,design blueprint,do spot research and compose papers etc.,which efficiently inspired students’learning interest and exploring spirit,cultivated their creative think-ing and researching ability.