ABSTRACT
The unexpected COVID-19 brings a great challenge to the cultivation of medical students’ professional spirit. However, the traditional cultivation mode of professional spirit is single, which could not meet the urgent needs for cultivating high-quality medical talents. Therefore, under the background of epidemic prevention and control, the optimization of the cultivation path of medical students’ professional spirit should be carried out in the medical colleges and universities to adapt the development requirements of the era. Firstly, taking reshaping the top-level design of the school as the starting point, providing institutional guarantee, improving the curriculum and optimizing the teaching staff. Secondly, focusing on improving teaching process, optimizing teaching design, innovating teaching forms and establishing model education. Lastly, taking realize the unity of knowledge, emotion and intention of medical students as the foothold, strengthening the study of theoretical knowledge, participating in the construction of campus culture and social practice activities. The trinity cultivation model of "school-teachers-students" will be constructed to collaboratively promote the benign development of medical students’ professional spirit cultivation.
ABSTRACT
Embedding the red doctor’s spirit into the cultivation field of medical students’ humanistic quality is a win-win strategy for creating the excellent doctor 2.0 plan in the new era and inheriting the red genes. Based on the in-depth interpretation of the morphological logic of embedding the red doctor’s spirit into the field of cultivating medical students’ humanistic quality, from the three dimensions of beginning, presence and development, this paper clearly captured many barriers, conflicts and contradictions faced in the process of the red doctor’s spirit embedded in the cultivation field of medical students’ humanistic quality. It is also necessary to break through the practical dilemma by creating the entry card and carrier of the red doctor’s spirit, stabilizing the field of educating people with the red doctor’s spirit, and expanding the development space of educating people with the red doctor’s spirit, so as to win and unite medical students and promote the implementation of the Healthy China strategy.
ABSTRACT
OBJECTIVE:To study the improving effects of argatroban on the brain damage of model rats with cerebral hemor-rhage. METHODS:50 SD rats were randomly divided into normal control group(equivalent normal saline),model group(equiva-lent normal saline),argatroban high,medium and low dose groups (0.75,1.5,3 mg/kg). All groups,except for normal control group,were reproduced models with cerebral hemorrhage,and the rats in each group were treated by corresponding drugs after 30 min,ip,once a day. The rats were executed after continuous administration for 3 days. The data was detected,including the con-tents of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),activity of cysteine-containing aspartic protease 3(Caspase-3), expressions of Bcl-2,Bax,matrix metalloproteinase-2(MMP-2)and MMP-9,and the phosphorylations of nuclear factor κB(NF-κB) p65 and IκBα. RESULTS:Compared with the normal control group,the contents of TNF-α and IL-1β,the activity of Cas-pase-3,the expressions of MMP-2,MMP-9 and Bax proteins were increased;the expression of Bcl-2 was decreased;and phos-phorylations of NF- κB p65 and IκBα in model group were increased,with significant differences(P<0.01). Compared with the model group,the contents of TNF-α and IL-1β,the activity of Caspase-3,the expressions of MMP-2,MMP-9 and Bax were de-creased;the expression of Bcl-2 was increased;and phosphorylations of NF-κB p65 and IκBα in argatroban low,medium and high dose groups were decreased,with significant differences (P<0.01 or P<0.05). And it was positively correlated with the dose. CONCLUSIONS:Argatroban has dose-dependent inhibition effects on the inflammatory cytokine secretion and apoptosis of brain tissue of model rats with brain hemorrhage,and the mechanism may be related to NF-κB signaling pathway.