ABSTRACT
In recent years,some studies have been shown that proton pump inhibitors(PPIs)not only play a role in digestive diseases,but it also has an important role in the treatment of breast cancer.PPIs,including omeprazole,pantoprazole,lansoprazole,esomeprazole,etc,improve the effect of breast cancer chemotherapy and induce breast cancer cell apoptosis by inhibiting intracellular proton excretion and increasing intracellular pH.This preview summarizes the study progress of PPIs in breast cancer and the potential application of PPIs in the treatment of breast cancer.
ABSTRACT
Objective To establish a kinetic spectrophotometric method for the determination of trace catechol in the waste water. Methods Trace catechol can sensitively inhibit the Arsenazo decolorization reaction with H2O2 catalyzed by Cu(Ⅱ)in dilute H2SO4 medium. Based on the changing of catalyzed reaction speed, a new inhibitory kinetic spectrophotometric method for the determination of trace catechol in the waste water was established. Results The optimum condition, kinetic parameters and reaction mechanism were investigated. It is shown that the linear range of determination was 0.2-1.8 mg/ L, the detection limit was 0.084 mg/L. The RSDs of ?A for 0.6 mg/L,1.12 mg/L and 1.6 mg/L catechol standard materials for 11 parallel determination were 2.4%, 1.2% and 1.6% respectively. The recovery rates were 98.0% and 96.0%. Conclusion This method can be used for determination of trace catechol in waste water with satisfactory results.