ABSTRACT
Objective To observe the effect of rhubarb enema on serum level of high mobility group protein B1 (HMGB1) in patients with severe acute pancreatitis (SAP).Methods A total of 60 cases of patients with SAP in our hospital were collected from October 2014 to October 2016,and were randomly divided into the observation group and control group (30 cases in each group).Serum levels of HMGB1 were dynamically detected on the 1st,3rd and 5th day after admission.The acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) was conducted.The recovery time of gastrointestinal function and time for continuous renal replacement therapy (CRRT) were observed.Results On the 1st day after admission,no statistically significant difference was found in serum level of HMGB1 between the two groups (P＞0.05).The serum level of HMGB1 in the observation group was obviously decreased on the 5th day after admission,which was lower than that in the control group,there was statistically significant difference(P＜0.05).In the observation group,the value of difference between serum level of HMGB1 on the 1st day after admission and that on the 3rd day after admission was significantly negatively related with the APACHE Ⅱ score on the 3rd day after admission(r=-0.604,P＜0.05).In the observation group,the remission time of abdominal pain and abdominal distension,first time of exhaust and defecation and time for CRRT were significantly shorter than those in the control group,there were statistically significant differences (P＜0.05).Conclusion Rhubarb could improvesymptoms and prognosis of patients with SAP through effectively inhibit the expression of HMGB1.
ABSTRACT
Objective:To investigate the effects of critical patients who were treated with percutaneous endoscopic gastrostomy(PEG)or percutaneous endoscopic jejunostomy(PEJ)with propofol at bedside.Methods:Tirty-eight patients,who were admitted in the ICU of the first affiliated hospital of the Chongqing medical university between August 2006 and December 2008,were randomly divided into P-group (propofol group)and DM-group.(diazepam combined with midazolam group).Electrocardio waveform,breath(Br),SPO2 and blood pressure were monitored and recorded from 10 min before operation to the time with the patients'Ramsay≤Ⅱafter operation (postoperative monitoring≥10min).And recorded the persistence time of operation,awaken time and subjective anamnesis were recorded at 30min after operation.Results:In the operation,the heart rate(HR)in P-group was(72.20?8.96)/min,which was significantly decreased compared with DM-group.The Br was(16.72?8.46)/min in P-group during operation,which was significantly decreased compared with DM-group,and the SPO2 in P-group was(94.87?3.52)%,which was significantly increased compared with DM-group(P
ABSTRACT
OBJECTIVE:To observe the effects of Tanreqing injection on the immune factors and clinical outcome in patients with ventilator associated pneumonia(VAP).METHODS:155 patients with VAP were randomly divided into trial group and control group.Serum levels of CRP,IL-6 and TNF-? were determined at 0,1,3,5 and 7 days after treatment.The chest X-ray results at 0 and 3 days after treatment were compared.The mechanical ventilation(MV)time and the successful rate of weaning from mechanical ventilation and the mortality rate were recorded.RESULTS:The serum levels of CRP,IL-6 and TNF-? in all 155 VAP patients were significantly higher than normal levels,at 5 days,serum levels of IL-6 and TNF-? in the trial group began to decrease significantly as compared with the control group(P
ABSTRACT
Objective:To study the sedative effect of disoprofol used in cases of multiple injury.Methods:13 cases of multiple injury were analyzed retrospectively.All patients were induced sedative with disoprofol.The change in vital signs,blcod gas analysis,PaO_2/FiO_2,etc were observed.Results:In the initial stage,cases of multiple injury could develop fidgety,increase in breath and blood pressure.Disoprofol could ameliorate the heart rate,reath,blood pressure and PaO2/FiO2 quickly.Conclusion:Disoprofol have the quick and positive sedative effect in comprehens-ive therapy for multiple injury.
ABSTRACT
Objective:To discuss the effect of tube changer in relieving difficult tracheal intubation.Methods:Three hundred and sixty-two patients with difficult tracheal intubation were selected to be aided with tube changer in the study.Electrocardiogram,blood pressure and oxygen saturation were observed.Results:The incidence of successful intubation was 93.9%(340/362).Twenty-two failing cases were treated by tracheotomy.Conclusion:Tube changer is a well assisting equipment in treating difficult tracheal intubation.By using tube changer,the intubation time in the patients with difficult intubations decreased and the incidence of successful intubation increases.It is recommended to adjust intubation on the basis of monitoring result.