ABSTRACT
Objective To investigate the clinical efficacy of cetylpyridinium chloride gargle in the treatment of oral candidiasis.Methods Collected 45 cases of oral candidiasis patients admitted in our hospital from April 2015 to April 2017.Among them, 24 patients were treated with cetylpyridinium chloride gargle and treated as observation group.Rinse treatment in 21 cases, set as the control group.The oral pain score, mucosal atrophy score and mucosal erythema score were compared between the two groups.The HAMA anxiety scale and HAMD depression scale were used to evaluate the psychological stress.The HAMA score, HAMD score, blood glucose and blood glucose were compared between the two groups.Insulin levels were compared between the two groups of patients after oral mucosal examination positive rate and the incidence of adverse reactions.Results After treatment, the oral pain score, mucosal atrophy score and mucosal erythema score were significantly lower in the observation group than in the control group, the difference was statistically significant(P<0.05).The HAMA score, HAMD score and blood glucose level were significantly lower in the observation group than in the control group, the insulin level was higher than the control group, the difference was statistically significant(P<0.05).The positive rate was 20.83%(5/24)in the observation group and 52.38%(11/21)in the control group.The positive rate of oral mucosal examination in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.05).There were no obvious adverse reactions during the treatment group.In the control group, only one case of oral mucosal congestion was found, but it was tolerable and disappeared after treatment.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The use of cetylpyridinium chloride gargle in the treatment of oral candidiasis can relieve oral pain, mucosal atrophy, erythema symptoms and stress state, effective control of oral infection, and no significant adverse reactions、high safety.
ABSTRACT
Objective To explore the relation of early time secretion function of Beta cell in newly diag-nosed type 2 diabetic patient and the changes of body weight following intensification therapy of insulin. Methods 237 newly diagnosed type 2 diabetic patients were divided into 1 kg lower group, the 1-5 kg group, the 5 kg above group. The maximum body weight and waist circumference were recorded. The present body weight and waist circum-ference were measured according to OGTT study, meanwhile,30 minuets blood sugars, the insulin and the C-peptide (C-P) level and the blood pressure(BP) and the insulin resistance index (HOMA-IR), the early insulin secretion index (△I30/△G30) was calculated. All cases were treated for 14 days. Results Early time secretion function of Beta cell in the group keeping above lose weight 5 kg was the worst, after treatment insulin secretion level were in-creased 1.12 times and 1.86 times in 1 kg lower group than in the 1-5 kg group and above 5 kg group. Conclusions Early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient is correlated with the maxi-mum body weight decrease.