ABSTRACT
Objective:To investigate the relationship between the expression mP53 and microvessel density urothelial carcinoma of the bladder and its clinical pathological significance. Methods: Immunohistochemistry(Envision method) was used to detect the expression of mP53 and FⅧ-RAg in 50 tissue specimens of primary BUC and 10 tissue specimens of normal mucosa of bladder .The results were analyzed with the clinic and pathological characters of BUC. Results: The expression of mP53 and MVD had significant differences between the tissues of normal mucosa of the bladder and the tissues of the BUC; but not related to the tumor size. mP53 and MVD value had correlation to different stages (according to UICC-TNM ), different grades (according to WHO), and recurrence(P
ABSTRACT
Objective:To prepare a pig model of obstructive sleep apnea-hypopnea syndrome(OSAHS) and to observe the hemodynamics and pathological characteristics of common carotid artery,so as to lay a foundation for further studying the effect of OSAHS on cardiovascular system.Methods: Twelve male small-type pigs were randomly divided into model group and control group(n=6).Animals in the model group were housed in a negative pressure chamber for 6 months to establish OSAHS model and those in the normal control group were fed routinely.After pigs in the model group presented the symptoms of OSAHS,the changes in hemodynamics of carotid artery were detected with color Doppler ultrasound.The morphological changes of common carotid artery were analyzed under light microscope and electron microscope.Results: Animal model of OSAHS was successfully created.The internal diameter of carotid artery of pigs in the model group was decreased,the intima was increased,and the peak-systolic mean velocity(S) and the resistance index(RI) were both increased compared with those of the control group(P