ABSTRACT
Objective To study the influence of Nictinamide on the endotheline(ET-1)in patienta with pulmonary arterial hypertension(PAH).Methods 66 cases of PAH were divided randomly into two groups (n=33for each):the Nictinamide treatment group and the control group.The changes of endotheline were compared before and after treatment.Results After treatment serum endotheline was significantly lower in the treatment group(P＜0.01),but there was no difference in the control group before and aftertreatment(P＞0.05).The significant difference was observed between treatment group and control group(P＜0.01).Conclusion Nictinamide will reduce the level of endothellne and confers some degree therapeutic and preventive value for PAH.
ABSTRACT
Objective To explore the level of serum neuron-specific enolase(s-NSE) and brain neuronal damage in the migraine patients during attack.Methods The level of s-NSE was assayed by ELISA in 26 patients with migraine during attack,23 patients with migraine at intervals and 20 normal controls .Results Content of s-NSE in migraine attack groups was significantly higher than that in the other two groups(P