ABSTRACT
Objective Many researches have demonstrated the lowing-intraocular pressure(IOP) effects of bimatoprost and timolol.However,no powerful evidence showed which drug has the better efficacy.This study was to perform a meta-analysis to evaluate the efficacy and tolerability of bimatoprost compared with latanoprost in lowing IOP.MethodsThis was a evidence-based medicine science study.Pertinent studies were identified through searches of PubMed,EMBASE,the Cochrane Liberary Controlled Trials Register and Chinese Biomedicine Database using the terms of timolol,blocardren,temserin,timoptic,bimatoprost,lumigan.The intensive searching by hand and up to October 1,2008 was also designed.ResultsSix randomized and controlled studies enrolling a total of 2 094 patients were included in the meta-analysis and three clinical indexes were analyzed.Bimatoprost was associated with greater decline value from baseline IOP in comparison with timolol(P＜0.01) with a weight mean difference -2.04 at final point(95% CI:-2.44 to -1.64).Numerically greater proportions of bimatoprost patients than timolol patients achieved the target IOP at 3 months(from 3 literature) and ＞6 months(from 2 literature) with a pooled RR of 1.87(95% CI:1.45 to 2.41),1.60(95% CI:1.36 to 1.90) (P＜0.01),respectively.Bimatoprost showed a more frequencies in the adverse effects such as conjunctival hyperemia and eyelash growth than timolol with an RR of 4.18 (95% CI:2.89 to 6.05),9.40 (95% CI:5.62 to 15.71).No obvious drug-related side effect was found from literature analysis included both drugs.Conclusion Searched literature offers grade A of evidences for the comparison clinical evaluation of therapy efficacy between bimatoprost and timolol in lowing IOP.Bimatoprost has a better efficacy in lowering IOP and reaching comparable proportions of patients with target IOP than timolol.Both agents are well tolerated.
ABSTRACT
Objective The analysis of hospitalization expenses contributes to effective measures for reducing medical costs.The authors investigated the hospitalization expenses and the influencing factors in orbital cavernous hemangioma (OCH) patients in Shanghai Changzheng Hospital.Methods In view of clinical diagnosis and treatment and social economics,we conducted a single factor analysis and a stepwise multiple linear regression analysis on the influencing factors of the hospitalization expenses of 81 OCH patients from 2002 to 2007.Results The six-year hospitalization expenses of the OCH patients averaged RMB $7 071.4 and the median was RMB $7 038.7,with the costs of surgical materials (54.3%),Western medicine (13.3%) and laboratory examinations (8.1%) as the top three figures.The single factor analysis and stepwise multiple linear regression analysis showed 8 factors to be statistically significant in influencing the hospitalization expenses of the OCH patients,namely,marital status,occupation,complications,anterior orbitotomy,previous treatment,proptosis,hospitalization year and preoperative hospital stay (P