A Study on Regional Cerebral Blood Flow of Normal Adults

The values for regional cerebral blood flow at rest were obtained from 60 right handed normal Korean adults(48 males, 12 females) with an age range of 24 to 69 years. The results were summarized as follows. 1) Mean rCBF were Fg ; 74.8+/-13.3ml/100g/min., Fw ; 19.2+/-3.1ml/100g/min, Wg ; 44.0+/-5.4% and CBF(inf) ; 39.8+/-7.6ml/100g/min. 2) In normal regional flow distributions throughout each hemisphere, values of Fg, Fw and CBF(inf) were higher in the frontal lobes and lower in the parietal lobes. A trend for higher values for Wg was seen in occipital and temporal lobes and lower values in the frontal lobes of both hemispheres. 3) When normal limits of the interregional variety values were predicted as mean ICV+2 SD(p<0.05), those values were Fg ; 12%, Fw ; 12%, CBF(inf) ; 10%, FFg ; 4% and Wg ; 10% of mean hemispheric rCBF. 4) There was a significant progressive decline of parameters of Fg, CBF(inf) and Wg with advancing age.

Influence of Kallikrein on the Cerebral Blood Flow in Rabbits

It is known that in animals with increased intracranial pressure the cerebral perfusion is curtailed, but whether it is caused by deranged responsiveness of the cerebral vessel is not known. Thus, it was attempted in this study to find out the changes of cerebrovascular response to Kallikrein in the rabbits with increased ICP(20mmHg) under urethane-anesthesia. 1) intracarotid arterial kallikrein elicited increases in cerebral blood flow and decreases in blood pressure and arterial resistance. 2) Cerebral blood flow was significantly decreased in rabbits with increased ICP in comparison with the control rabbits. 3) Intraarterial kallikrein caused dose-depent increases of cerebral blood flow in both groups, but responses were significantly reduced in ICP-elevated group. 4) Kallikrein produced dose-dependent hypotensive effect in both groups with no significant difference between both groups. 5) Cerebrovascular resistance was greater in rabbits with elevated ICP(20 mmHg), but kallikrein induced decreases of cerebrovascular resistance in both groups to the same degree, 6) Above results suggested that increased ICP reduces the cerebral blood flow by increasing cerebrovascular resistance, but it does not modify the reponsiveness of cerebral vessel to kallikrein.

Two Cases of Arachnoid Cyst of the Middle Cranial Fossa

With the advent of computed tomography (CT), the intracranial arachnoid cyst of which the diagnosis had been unlikely to be made before is detected without difficulty now. Reports of intracranial arachnoid cysts have increased in number. It appears on CT scans as a sharply circumscribed hypodense lesion of CSF density, most frequently located in the middle cranial fossa. It has no direct communication with the subarachnoid or ventricular systems. Recently we have experienced two cases of intracranial arachnoid cyst of the middle cranial fossa. Pathogenesis, diagnosis and treatment of the intracranial arachnoid cyst will be reviewed.