ABSTRACT
A recent genetic study of alopecia areata shows that the patients with early onset, severe, familial group could be separated from the patients with later onset, milder severity with good prognosis in their genetic background. We have experienced an intractable clinical course of alopecia areata in dizygotic twin brothers and have come to sympathise with the genetic influence of the disease. The alopecia areata of the two brothers began for both at about 10 years of age and became severe and persistent over the twenties up to the present times. All treatments failed. The patients were thought to be an example showing the importance of genetic influences in the treatment of alopecia areata.
Subject(s)
Humans , Alopecia Areata , Alopecia , Prognosis , Siblings , Twins, DizygoticABSTRACT
Merkel cell carcinoma is an uncommon malignancy of the skin that was first described by Toker in 1972 and occasionally found concurrent with other malignancies such as squamous cell carcinoma, basal cell carcinoma or, as in the present study, with Bowen's disease. We report a unique case of Merkel cell carcinoma coexisting with Bowen's disease on the left forearm of a 42-year-old man who had a past history of multiple Bowen's disease. The tumor was excised and the specimen was examined histopathologically. The tumor cells exhibit trabecular, cord-like arrangement in the dermis, partly extending into subcutaneous tissue without involvement overlying epidermis, where Bowen's disease lesion was absent but the peripheral patch area exhibit Bowen's disease. The tumor cells in the dermis were positive for neuron-specific enolase and chromogranin. This is the first report of a case of Merkel cell carcinoma associated with Bowen's disease in Korea.
Subject(s)
Adult , Humans , Bowen's Disease , Carcinoma, Basal Cell , Carcinoma, Merkel Cell , Carcinoma, Squamous Cell , Dermis , Epidermis , Forearm , Korea , Phosphopyruvate Hydratase , Skin , Subcutaneous TissueABSTRACT
BACKGROUND: Xanthelasma palpebrarum does not regress spontaneously, its appearance is often seen as cosmetically disturbing. Treatment of xanthelasma palpebrarum may prove difficult due to its delicate location at the periorbit and sometimes its extensive dimension. Treatments include excision, electrodesiccation, chemical cautery and laser surgery. OBJECTIVE: This study was designed to evaluate the effect of a CO2 laser for the treatment of xanthelasma palpebrarum. METHODS: Twenty patients with a total of 56 xanthelasma lesions, were treated with a CO2 laser. The Follow-up period of observation was between 12 and 84 months. RESULTS: All lesions could be removed completely with a single laser treatment. Only transient pigmental change (hypopigmentation 1/20, hyperpigmentation 1/20) was observed without scarring. 8 patients developed a recurrence of xanthelasma. CONCLUSION: The CO2 laser represents an effective means for treating xanthelasma, but recurrence is common.
Subject(s)
Humans , Cautery , Cicatrix , Follow-Up Studies , Hyperpigmentation , Korea , Laser Therapy , Lasers, Gas , RecurrenceABSTRACT
Angiosarcoma is a rare and highly malignant vascular tumor of endothelial cell origin. Cutaneous angiosarcoma usually occurs on the scalp and face of the elderly person, frequently in the sixth and seventh decade. Unusually, we experienced a case of angiosarcoma of the scalp in a 12-year-old girl. The patient had a solitary, well-demarcated 0.7X0.7cm sized, non-tender, blue-violaceous to gray-black colored, crusted papule on the vertex for 2 months. She was treated by wide surgical excision only but no recurrence in the last eight years after excision.
Subject(s)
Aged , Child , Female , Humans , Endothelial Cells , Hemangiosarcoma , Recurrence , ScalpABSTRACT
Hydroxyurea is an antitumor agent that has attained an important role in the management of myeloproliferative syndromes. Its mechanism of action is not fully understood, but it appears to affect DNA synthesis and genetic control of cell replication by inhibiting the conversion of ribonucleotides in deoxyribonucleotides. Cutaneous side effects such as xerosis, hyperpigmentation, nail changes, skin ulceration, alopecia, and palmoplantar keratoderma may occur, especially with long-term treatment. We report a case of 65-year-old chronic myelogenous leukemia(CML) patient showing various cutaneous manifestations after receiving long-term hydroxyurea therapy.
Subject(s)
Aged , Humans , Alopecia , Deoxyribonucleotides , DNA , Hydroxyurea , Hyperpigmentation , Keratoderma, Palmoplantar , Ribonucleotides , Skin UlcerABSTRACT
Phakomatosis pigmentovascularis(PPV) was first described in 1947 as a distinctive association of vascular and pigmentary nevi by Ota et al. Hasegawa et al subclassified the disorder into eight types and type I a is characterized by the coexistence of nevus flammeus and nevus pigmentosus et verrucous, which is not associated with systemic organ involvement. PPV type I a is relatively rare and a case with multiple pyogenic granulomas developed in pregnancy, is not reported yet. We present a case of PPV type I a with multiple pyogenic granulomas developed in pregnancy within nevus flammeus in a 29-year-old female.
Subject(s)
Adult , Female , Humans , Pregnancy , Granuloma, Pyogenic , Neurocutaneous Syndromes , Nevus , Port-Wine StainABSTRACT
Median raphe canal is an uncommon disease and represents a defect abnormality of the male genitalia. It occurs along the ventral median raphe from the glans penis to the anus. Histologically the canal is lined by stratified squamous epithelium which dose not communicate with the urethra. Surgical excision is the treatment of choice. Recently we observed a 25-year-old male patient who had had a median raphe canal located in the ventral aspect of penis.