ABSTRACT
Objective To conduct the comparative study on postoperative serum CD 40 ligand (CD40L ) , tumor necrosis factor-α(TNF-α) and interleukin 6(IL-6) levels and arrhythmia in the patients with pneumo-nectomy and pulmonary lobectomy .Methods T he clinical data in 120 cases of non-small cell lung cancer (NSCLC) treated with lung cancer radical resection in this hospital from March 2013 to March 2016 were ret-rospectively analyzed ,among them 20 cases of thoracoscopic pneumonectomy served as the control group , w hile the other 100 cases of thoracoscopic pulmonary lobectomy served as the observation group .T he number of lymph node dissection ,operative time ,drainage time ,postoperative pain score ,intraoperative bleeding vol-ume and hospital stay time were compared between the two groups .Serum TNF-α,CD40L and IL-6 levels be-fore and after operation and occurrence of complications were compared between the two groups .Results The operative time ,drainage time ,postoperative pain score ,intraoperative bleeding volume and hospital stay time in the observation group were significantly lower than those in the control group ,the differences had statistical significance (P<0 .05) .The incidence rate of arrhythmia in the observation group was 5 .00％ ,which was sig-nificantly lower than 45 .00％ in the control group ;the total incidence rate of complications in the observation group was 12 .00％ ,which was significantly lower than 65 .00％ in the control group ,the difference was statis-tically significant (P<0 .05) .The serum TNF-α,CD40L and IL-6 levels before and after operation had statisti-cal difference between the two groups (P<0 .05) .Conclusion Compared with pneumonectomy ,adopting pul-monary lobectomy in the patients with lung cancer has shorter hospital stay time and drainage time ,less blood loss ,milder pain and slight postoperative inflammatory reaction and lower incidence rate of arrhythmia and other complications ,therefore ,w hich can serve as the first choice of operation method for treating lung cancer .