ABSTRACT
Objective To investigate the therapeutic effect of the lateral fissure opened intraoperative cerebral con-tusion sylvian cistern , basal cistern for improving the cerebral vasospasm. Methods A total of 106 patients with cerebral contusion in lateral fissure area were randomly divided into 2 groups. The control group was given conventional craniotomy to clear focal cerebral contusion of hematoma. And the experimental group was further to fully open sylvian cistern, jugular vein pool, endplate pool and basal cistern on the basis of the conventional craniotomy to remove the brain contusion and hemato-ma. The levels of endothelin 1 (ET-1) in plasma and cerebrospinal fluid (CSF) were detected postoperative 3, 7 and 14 days. The Glasgow coma scale (GCS) score, ICU guardianship time and total length of hospital stay were observed on discharge and followed up for 3 months in two groups. The rate of good prognosis was compared between two groups. Results There were significant differences in ET-1 levels of plasma and CSF at different time points (plasma Ftime = 603.436 and CSF Ftime =684.276 ) between two groups of patients (plasma Fgroup=272.531 and CSF Fgroup=317.641). The ET-1 levels were signifi-cantly lower after 7 d and 14 d treatment in experimental group, but no significant difference 3d after operation between two groups (P<0.01). The GCS score was significantly higher on discharge in experimental group than that of control group. The values of ICU guardianship time and the total hospitalization time were both significantly lower in experimental group than those of control group (P<0.01). The rate of good prognosis was significantly higher in experimental group than that of con-trol one [78.85%(41/52) vs 51.85%(28/54),χ2=8.496, P<0.01]. Conclusion Openning side crack pool and basal cistern in the surgical treatment of traumatic brain injury can improve the cerebral vasospasm and prognosis.
ABSTRACT
Objective To investigate the expression of endostatin and angiopoietin (Ang)-2 in human ghoma and its significance. Methods The expression of endostatin and Ang-2 were measured by immunohistochemistry and endostatin mBNA by hybridization in situ in 108 cases of brain glioma and 5 cases of normal brain tissues. Results The expression of endostatin (0.0657±0.0038)and Ang-2 (0.0286± 0.0042) were significantly higher in grade Ⅲ-Ⅳ glioma patients than those in grade Ⅰ-Ⅱ ghoma patients (0.0349±0.0048,0.0084±0.0018, respectively) and normal brain tissues (0,0)(P<0.01). The expression of endostatin mRNA were significantly higher in grade Ⅲ-Ⅳ glioma patients (0.0310±0.0041) than that in grade Ⅰ-Ⅱ glioma patients (0.0152±0.0031) and normal brain tissues (0)(P< 0.01 ). Theratio of endo-stalin to Ang-2 was negatively rehted to the grade of glioma (r=-0.810,P <0.01). Conclusion The interaction of endostatin and Ang-2 plays an important role in the invasive growth and malignant development of human glioma, and may be related to the prognosis and the malignant degree of glioma.