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Objective To explore the principle,effect and method of percutaneous AiDi injection for treatment of implanted VX2 liver tumor with ultrasound guidance.Methods Twenty-eight New Zealand white rabbits with implanted VX2 liver tumors were randomly divided into 3 groups:AiDi injection group (n=12) ,percutaneous ethanol injection (PEI) group (n=8) ,and physiological saline group (n=8) .Two weeks after transplantation,the drugs were injected into tumors of all the rabbits once every 3 days.After 4 times injection,the rabbits were killed.The tumors were measured with 64-slice CT,while the rate of tumor necrosis,the volume of tumor and the growth rate of the tumor were calculated.Liver and kidney function tests (AST,ALT,ALP and BUN) as well as white blood eell counts were assessed before and after treatment,and CT examination was performed at the same time.The morphological and the ultramicrostructural changes were also investigated under light microscope or electron microscope.Results Tumors in all groups kept growing after the procedure.Among all 3 groups,tumor growing rate for AiDi injection group was the lowest and the necrotic rate was the highest (P＜0.05) ,while no significant difference was found between AiDi injection group and PEI group (P＞0.05) .Apoptotic index in AiDi injection group was significantly higher than that in PEI group and physiological saline group (P＜0.05) .There was no evident change of liver and kidney function before and after treatment in AiDi injection group and PEI group (P＞0.05) .Conclusion AiDi injection can induce apoptosis of liver VX2 tumor cells.Percutaneous AiDi injection therapy can obviously inhibit and destroy liver VX2 tumor cells.
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Objective To evaluate the CT appearance of the hepatocellular carcinomas (HCC) supplied by the right inferior phrenic arteries (RIPA). Methods A total of 195 consecutive cases of HCCs examined with helical CT and arteriography were studied. 15 proven HCCs cases were supplied by the RIPA. On arterial phase CT images, the size of the RIPA, the left inferior phrenic arteries, and HCCs were measured, and the origin of RIPA and the location of HCCs were recorded. The CT findings in these 15 cases were correlated with arteriographic images. Results CT showed RIPA on the right diaphragmatic crus as high attenuation in all patients. The origin of RIPA was demonstrated in 11 cases. The diameter of the RIPA (3.1?1.1) mm was larger than that of the left inferior phrenic artery (1.3?0.4) mm ( P
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Objective:To research the relationship between anteroposterior aneurysms on communicating branches and the hemodynamic changes in Willis circle.Methods:Cerebral DSA findings in 208 cases were retrospectively analyzed.Results:A1 dominant signs in aneurysms group of the anterior communicating atery was more common than those in the control group( P 0.05).Conclusion:The development of cerebral aneurysms on anterior communicating segment is related with the hemodynamic changes in the anterior circle of Willis,while hemodynamic changes in the posterior circle of Willis has no relation to the aneurysms on the ipsilateral internal carotid-posterior communicating artery junction.