ABSTRACT
Objective To observe the therapeutic effect of Guizhi Decoction plus Yupingfeng Powder for chronic urticaria and its effect on serum total IgE level.Methods One hundred and twenty patients were randomly divided into treatment group,control group 1 and control group 2,40 cases in each group.The treatment group was treated with Guizhi Decoction,Yupingfeng Powder and Loratadine Tablets orally,the control group 1 was given intramuscular injection of Bacillus Calmette-Guerin polysaccharide nucleic acid and oral use of Loratadine Tablets,and the control group 2 was only given oral use of Loratadine Tablets.The course of treatment covered 5 weeks.The levels of serum total IgE in the three groups were determined before and after treatment,and the therapeutic effect was evaluated after treatment.Results (1) The total effective rate was 85.0％ in the treatment group,80.0％ in the control group 1,and 55.0％ in the control group 2.The effect of control group 1 and the treatment group was superior to that of the control group 2 (P＜ 0.05),but the difference was insignificant between the treatment group and control group 1 (P＞ 0.05).(2)Before treatment,the serum total IgE level of the three groups was higher than that of the normal control group (P ＜ 0.05).After treatment,the serum total IgE level of the three groups was obviously decreased (P ＜ 0.05 compared with that before treatment);the inter-group comparison results showed that the effect of the treatment group and control group 1 on decreasing the serum total IgE level was superior to that of the control group 2(P ＜ 0.05),while the effect of the treatment group was similar to that of the control group 1 (P ＞0.05).(3) During the treatment,blood routine examination indexes and hepato-renal function of the three groups showed no abnormal changes,neither adverse reaction was shown.Conclusion Guizhi Decoction plus Yupingfeng Powder exerts certain therapeutic effect for the treatment of chronic urticaria,and can decrease the serum total IgE level,thus to stabilize the curative effect and reduce the recurrence.
ABSTRACT
Objective To compare the clinical features between measles in adult and juvenile patients,and to provide references for correct diagnosis and early prevention of measles.MethodsClinical data werle retrospectively collected from and analyzed for 239 inpatients with measles in the hospital.Results The ratio ofmales to females was 1∶1.4 and 2.9∶1 among adult patients(n=129)and juvenile patients (n=110),respectively.The average duration from fever to eruption was shorter in adults than in juveniles (2.43±1.34)days vs(4.26±2.69)days,(t=6.48，P＜0.01).The incidence of hyperthermia,catarrhal symptoms,Koplik spots,conjunctival hyperemia,diarrhea and thrombocytopenia was 33.0%,65.0%，78.3%,84.5%,42.7%and 17.8%,respectively aniong adult patients,14.5%,50.9%,56.4%,69.0%,22.9%and 9.0%,respectively among juveniles;the difference was significant between the two groups in all the above rates (P＜0.01 or 0.05).Meanwhile,elevated activity of lactate dehydrogenase(LDH),creatine kinase(CK),MB isoenzyme of creatine kinase (CK-MB),aspartate aminotransferase(AST),alanine aminotransterase(ALT)was found in 63.6%,43.4%,38.0%,59.7%and 48.1%of the adult inpatients,respectively,42.7%,28.0%,20.0%,41.8%and 30.9% of juvenile patients,respectively,with the difference being statistically signifi cant(x2=10.38,5.95,6.73,7.59,7.27,P＜0.01,0.05,0.01,0.01,0.01,respectively).Furthermore,theincrease of LDH activity correlated with the occurrence of complications(x2=12.60,P＜0.01).Bronchopneumonia was diagnosed in 16.3%of adult inpatients with measles and 31.8%of juvenile inpatients(t=7.99,P＜0.01).Conclusions Measles in adults tends to have a more severe clinical symptom but a better prognosis compared with measles in juveniles;however,this 1s often ignored in clinical practice.