ABSTRACT
Objective To explore the clinical value of combined detection of lysophosphatidic acid(LPA),tumor-specific growth factor(TSGF)and carbohydrate antigen 1 9-9(CA1 9-9)in the diagnosis of non-small cell lung cancer(NSCLC).Methods The ser-um levels of LPA,TSGF and CA1 9-9 in 97 cases of patients with NSCLC(NSCLC group),43 cases of patients with benign lung disease(benign lung disease group)and 50 cases of healthy individuals(healthy control group)were detected,and diagnostic value of combined detection of these three tumor makers in the diagnosis of NSCLC was analysed.Results Serum levels of LPA,TSGF and CA1 9-9 in the NSCLC group were significantly higher than those in the benign lung disease group and healthy control group,had statistically significant differences(P <0.05).The sensitivity and specificity of combined detection of LPA,TSGF and CA1 9-9 was 68.63% and 37.1 7% respectively,and the sensitivity was higher than that of single detection and combined detection of any two of the three indicators.Conclusion Combined detection of tumor markers can improve the sensitivity in the diagnosis of NSCLC, which could provide reliable laboratory references for diagnosing NSCLC.
ABSTRACT
Objective To investigate the clinical value of the procalcitonin (PCT)measurement in preventing the occurrence of the bacterial drug resistance and reducing the overuse of antibiotics.Methods 400 inpatients without thyroid dysfunction but with suspected bacterial infections in our hospital from June 2012 to April 2013 were screeded out.Under the patient′s informed consent and the allowable condition,the routine treatment group (200 cases )and the PCT guidance group(200 cases )were obtained. Then,the antibiotic use time,hospitalization duration and hospitalization expenses were retrospectively anlyzed in the two groups. Meanwhile,the PCT guidance group was dynamically monitored.Results The mean antibiotic therapeutic time in the PCT guidance group was shorter than that in the routine treatment group;the average hospitalization days had statistical difference between the two groups (P<0.001 );the antibiotic expenses accounted for 26.4% and 32.0% of the hospitalization medication costs,which also had statistically significant difference (P <0.001).The clinical pulmonary infection scores(CPIS)were not compared because of lacking microbiology indicators.During the dynamic monitoring,when PCT<0.10 ng/mL,the antibiotic use was stopped,when PCT≥0.25 ng/mL,the antibiotic use was restored,when PCT≥0.25 ng/mL or≥0.50 ng/mL for consecutive 3 d,adjusting the antibiotics,dose or administrating route obtained significantly therapeutic effect,which indicating that PCT could be used for the prognosis judgement of the disease.Conclusion The once measurement of serum PCT could guide for diagnosing and assessing the infection degree,while its continuous measurement could guide the antibiotic use and make the prognosis on the disease condition.
ABSTRACT
Objective To further confirm the clinical value of serum total bile acid (TBA) in hepatic lesion in patients with hemolytic disease of the newborn.Methods Enzyme circulation assay was applied to measuring in 68 patients with hemolytic disease of the newborn. Total bilirubin (TBIL), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) were measured simultaneously.Results The serum level of TBA was (27.63±4.83) mmol/L in haemolysis group, significantly higher than that in control group (14.92±6.87) mmol/L (P<0.01). The positive rate accounted for 70.59% (48/68) in haemolysis group, and serum level of TBA was positively correlative with liver functional parameters (TBIL, ALT, GGT and ALP).Conclusion Serum TBA may be used as an indicator of therapeutic effect monitoring and prognosis evaluation of hepatic lesion in patients with hemolytic disease of the newborn.