ABSTRACT
Objective:To study the inhibitory activity of sulbactam,clavulanic acid and tazobactam on the clinical bacterium which produces ?-lactamase.Compare the inhibitory ways and inhibitory effects of three inhibitors.Methods:Study of inhibitory activity of these three ?-lactamase on the 8 bacteria producing ?-lactamase by spectrophotometry.Inhibition constant(K)iwere obtained from dixon plot and the relevance kinetic parameters of inhibition were calculated.Result:All inhibition modality of 3?-lactamase inhibitors are the competitive inhibition.Sulbactam is the weakest of the relative inhibitory effect of three inhibitors,and the strongest is tazobactam. Conclusion:There were differences between inhibitory effects of three enzyme inhibitors on different strains producing ?-lactamase.
ABSTRACT
Objective To study the protective effect of ginger extract on RBC of X-ray irradiated mice. Methods Mice were given extract of ginger with three doses, namely 9.3 ml/kg bw, 4.7 ml/kg bw and 2.3 ml/kg bw before X-ray irradiation(dose was 2.0 Gy, for two times, the interval was 24 h), 48 hours after the last irradiation, the blood samples were collected and RBC, HCB, HCT, MCV, MCHC, MCH, RDW were examined. Results Compared with the exposed control, RBC, HCB, HCT increased and MCH, RDW decreased significantly in ginger treated groups. Conclusion The ginger extract has a certain effect to prevent RBC from damaging induced by X-ray irradiation in mice.