ABSTRACT
No abstract available.
Subject(s)
Adult , Humans , Abscess , Diabetes Mellitus , Pyelonephritis , Urachal CystABSTRACT
Sunitinib as a multitarget tyrosine kinase inhibitor is one of the anti-tumor agents, approved by the United States Food and Drug Administration to use treat gastrointestinal stromal tumor and metastatic renal cell carcinoma. The agent is known to commonly induce adverse reactions such as fatigue, nausea, diarrhea, stomatitis, esophagitis, hypertension, skin toxicity, reduciton in cardiac output of left ventricle, and hypothyroidism. However, it has been reported to rarely induce adverse reactions such as nephrotic syndrome and irreversible reduction in renal functions, and cases of intestinal perforation or pneumatosis interstinalis as such reactions have been consistently reported. In this report, a 66-year old man showing abdominal pain had renal cell carcinoma and history of sunitinib at a dosage of 50 mg/day on a 4-weeks-on, 2-weeks-off schedule. Seven days after the third cycle he was referred to the hospital because of abdominal pain. Computed tomography showed pneumoperitoneum with linear pneumatosis intestinalis in his small bowel. The patient underwent surgical exploration that confirmed the pneumatosis intestinalis at 100 cm distal to Treitz's ligament. We report a rare case of intestinal perforation with pneumatosis intestinalis after administration of sunitinib to a patient with metastatic renal cell carcinoma.
Subject(s)
Aged , Humans , Male , Antineoplastic Agents/adverse effects , Carcinoma, Renal Cell/drug therapy , Drug Administration Schedule , Indoles/adverse effects , Intestinal Perforation/diagnosis , Kidney Neoplasms/drug therapy , Lung/diagnostic imaging , Pneumatosis Cystoides Intestinalis/diagnosis , Positron-Emission Tomography , Pyrroles/adverse effects , Tomography, X-Ray ComputedABSTRACT
Patent ductus arteriosus (PDA) is a rare clinical finding in adult patients. Considering the increase in cases of PDA discovered incidentally on echocardiograms at young ages, and the life-shortening effect of PDA, it is rare to diagnose PDA in old patients. We report a case of an 80-year-old patient who experienced symptoms of congestive heart failure showed findings suggestive of PDA in echocardiogram and confirmed the diagnosis through a cardiac catheterization and a coronary angiography. After percutaneous occlusion of PDA with an Amplatzer duct occlusion device, symptoms related to congestive heart failure improved.
Subject(s)
Adult , Aged , Humans , Cardiac Catheterization , Cardiac Catheters , Coronary Angiography , Ductus Arteriosus, Patent , Estrogens, Conjugated (USP) , Heart FailureABSTRACT
Plasma cell myelomas generally manifest as bone or soft-tissue tumors with variable mass effects, pain, and infiltrative behavior. Extramedullary involvement occurs most commonly in the spleen, liver, lymph nodes, and kidneys, but intracranial involvement in plasma cell myeloma is a rare extramedullary manifestation. These authors recently encountered a case of intracranial involvement of plasma cell myeloma. A 69-year-old man was hospitalized for headache and mental changes. Brain CT showed subdural hemorrhage caused by plasma cell myeloma. Plasma cell myeloma with intracranial involvement has poor prognosis, and the patient in this case died from acute complications, such as subdural hemorrhage. Based on this case report, it is suggested that more effective treatment regimens of plasma cell myeloma with intracranial involvement be developed. Moreover, a screening method and decision on the appropriate time for intracranial involvement are needed for plasma cell myeloma patients.
Subject(s)
Aged , Humans , Brain , Brain Neoplasms , Headache , Hematoma, Subdural , Kidney , Liver , Lymph Nodes , Mass Screening , Multiple Myeloma , Plasma , Plasma Cells , Prognosis , SpleenABSTRACT
Arterial remodeling is commonly observed in human atherosclerosis. It is a heterogeneous response ranging from positive remodeling to negative remodeling. Negative remodeling is a condition in which the vessel area decreases in size, often as a result of a structural change in the coronary vessel wall. But its contribution to myocardial ischemia in a de novo lesion has not been clearly shown. A 51-year-old female with exertional angina was admitted to our hospital. Coronary angiography was performed, revealing a severe stenosis at the middle part of the right coronary artery (RCA). Although we predilated ballooning at the middle RCA, the degree of stenosis did not improve. Thus intravascular ultrasound (IVUS) was performed. The lesion was not nearly showed plaque burden and severe negative remodeling. Though the cross-sectional narrowing percentage was significant, we decided to medical treatment for fearing coronary perforation by stenting. This case report intends to emphasize that severe coronary stenosis should be performed IVUS before the stenting. We describe a rare case with severe negative remodeling at the middle part of the RCA without atheroma plaque.
Subject(s)
Female , Humans , Atherosclerosis , Constriction, Pathologic , Coronary Angiography , Coronary Stenosis , Coronary Vessels , Glycosaminoglycans , Myocardial Ischemia , Plaque, Atherosclerotic , StentsABSTRACT
Kidney transplant recipients are more susceptible to rhabdomyolysis because of both the numerous medicines they take, such as immunosuppressants, lipid-lowering agents, and antihypertensive agents, and post-transplantation complications, such as posttransplantation diabetes mellitus and hyperuricemia. Pure hypothyroidism is a rare cause of rhabdomyolysis, and few cases of rhabdomyolysis induced by hypothyroidism have been reported in kidney transplant recipients. We report a case of rhabdomyolysis induced by unrecognized hypothyroidism in a kidney transplant patient, and discuss hypothyroidism and other precipitating factors as a cause of rhabdomyolysis, with a review of the literature.