Nevus Sebaceus Associated with Trichilemmoma, Trichilemmal Carcinoma and Trichoblastoma / 대한피부과학회지

Nevus sebaceus is located on the scalp or the face as a single lesion and is already present at birth. In adulthood, various types of appendage tumor may develop secondarily within the lesion of the nevus sebaceus. A syringocystadenoma papilliferum is the most common secondary benign tumor that has been found in 8% to 19% of the lesion of nevus sebaceus. The malignant tumors arising from nevus sebaceus are basal cell carcinoma, squamous cell carcinoma, apocrine carcinoma and malignant eccrine poroma. The combination of a variety of tumor was found in the lesion of nevus sebaceus. We report a case of nevus sebaceus in a 66-year-old male associated with trichilemmoma, trichilemmal carcinoma and trichoblastoma.

Neonatal Lupus Erythematosus: Showing Target-like Skin Lesions / 대한피부과학회지

Neonatal lupus erythematosus(NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, particularly autoantibodies of Ro family. The patient with NLE exhibits one or more of the following findings: congenital heart block, cutaneous lupus lesions, hepatobiliary disease and hematologic disorders(thrombocytopenia, anemia). We report a case of NLE in a 2-week-old male infant, born of a clinically asymptomatic mother, presenting multiple, round, target-like lesions which have not been reported in the English and Korean literature. Both infant and mother were positive for anti-SSA/Ro and anti-SSB/La.

Eosinophilic Ulcer of the Tongue / 대한피부과학회지

Eosinophilic ulcer of the tongue, which is characterized by an ulcer with indurated and elevated border that is usually covered by a pseudomembrane, is a benign reactive lesion. It rapidly develops, and spontaneously resolves in a few weeks. It occurs mostly on the tongue, and has a peak onset in the fifth to sixth decades of life. We experienced an eosinophilic ulcer of the tongue in a 65 years old man. The patient showed a single ulcer on right side of his tongue, but had neither subjective symptom nor previous oral or genital ulcers, arthralgia, and erythema nodosum-like skin lesions. The ulcer was 1.2 cm sized with indurated border. Histopathologically, the lesion exhibited ulceration, and a mixed, dense cellular infiltrate composed of eosinophils, lymphocytes, and neutrophils extended from the dermis into muscular layer. The lesion had completely disappeared in two weeks, and did not recur yet for follow-up period of nine months. Only one case of eosinophilic ulcer of oral mucosa have been reported in the Korean dermatological literature, so it is the second case of eosinophilic ulcer of the tongue in Korea.

Nevus Sebaceus Associated with Secondary Tumors / 대한피부과학회지

BACKGROUND: Frequent association of nevus sebaceus with other skin appendage tumors and with apocrine glands suggests that the nevus sebaceus may be derived from the primary epithelial germ. Syringocystadenoma papilliferum was found most frequently in the nevus sebaceus. A number of cases have been reported, but extensive studies on the secondary tumors of nevus sebaceus are rare in Korea. OBJECTIVES: The purpose of this study was to investigate characteristic clinical features in Korean patients with the secondary tumors of nevus sebaceus. MATERIALS & METHODS: Enrolled were total 136 patients confirmed as nevus sebaceus at the Chungnam National University Hospital, the Dankook University Hospital, and the Chungbuk National University Hospital from March 1993 to February 2003 for this study. And we reviewed the Korean Journal of Dermatology and the Annals of Dermatology for nevus sebaceus with secondary tumors. RESULT: The results were as follows; Total 45 cases were included from 23 males and 22 females. The male/female ratio was similar. Trichoblastoma(86% in female) and basal cell carcinoma(67% in female) were more frequent in female than in male. Mean age was 38.7 years(range 1.5 years to 71 years). All malignant tumors except basal cell carcinoma developed beyond 40 years of age. In the malignant tumors, 19(95%) of 20 cases developed in the scalp. However, in the benign tumors, 44(86.3%) of 51 cases developed in the scalp and 7(13.7%) of 51 cases in the face. Tumors of one type developed in 29 cases and tumors of more than two types developed in 16 cases. The total seventy eight tumors were composed of 23 malignant tumors and 55 benign tumors. Basal cell carcinoma and syringocystadenoma papilliferum were the most common tumor in each group respectively. Although trichoblastoma was not counted as the most common tumor, we suggest that it might be the most frequent tumor in secondary tumors associated with nevus sebaceus because differential diagnosis between trichoblastoma and basal cell carcinoma was so difficult that many cases of trichoblastoma were misdiagnosed as basal cell carcinoma.

Nevus Sebaceus Associated with Secondary Tumors / 대한피부과학회지

BACKGROUND: Frequent association of nevus sebaceus with other skin appendage tumors and with apocrine glands suggests that the nevus sebaceus may be derived from the primary epithelial germ. Syringocystadenoma papilliferum was found most frequently in the nevus sebaceus. A number of cases have been reported, but extensive studies on the secondary tumors of nevus sebaceus are rare in Korea. OBJECTIVES: The purpose of this study was to investigate characteristic clinical features in Korean patients with the secondary tumors of nevus sebaceus. MATERIALS & METHODS: Enrolled were total 136 patients confirmed as nevus sebaceus at the Chungnam National University Hospital, the Dankook University Hospital, and the Chungbuk National University Hospital from March 1993 to February 2003 for this study. And we reviewed the Korean Journal of Dermatology and the Annals of Dermatology for nevus sebaceus with secondary tumors. RESULT: The results were as follows; Total 45 cases were included from 23 males and 22 females. The male/female ratio was similar. Trichoblastoma(86% in female) and basal cell carcinoma(67% in female) were more frequent in female than in male. Mean age was 38.7 years(range 1.5 years to 71 years). All malignant tumors except basal cell carcinoma developed beyond 40 years of age. In the malignant tumors, 19(95%) of 20 cases developed in the scalp. However, in the benign tumors, 44(86.3%) of 51 cases developed in the scalp and 7(13.7%) of 51 cases in the face. Tumors of one type developed in 29 cases and tumors of more than two types developed in 16 cases. The total seventy eight tumors were composed of 23 malignant tumors and 55 benign tumors. Basal cell carcinoma and syringocystadenoma papilliferum were the most common tumor in each group respectively. Although trichoblastoma was not counted as the most common tumor, we suggest that it might be the most frequent tumor in secondary tumors associated with nevus sebaceus because differential diagnosis between trichoblastoma and basal cell carcinoma was so difficult that many cases of trichoblastoma were misdiagnosed as basal cell carcinoma.

Nevus Lipomatosus Superficialis on the Dorsal Foot

Nevus lipomatosus superficialis is a fairly uncommon disease characterized by ectopic fat tissue in the dermis. Lesions most commonly occur on the lower trunk, especially on the back, buttocks or abdomen. Rarely, lesions also occur on the knee, axilla, arm, ear and scalp. To our knowledge this is the first case of nevus lipomatosus superficialis developing on the dorsal foot.

Cutaneous Metastasis from Prostatic Cancer

Cutaneous or subcutaneous metastases occur in 2% to 9% of visceral malignancies. Skin metastases are seen most commonly from carcinomas of the breast, lung, large intestine. Skin metastases of prostatic origin are quite uncommon and preferentially localized to the lower abdomen and genital area. Two cases of cutaneous metastases of prostatic origin have been reported in the Korean dermatological literature in our review. We report a case of cutaneous metastases from prostatic cancer

A Case of Multiple Lichen Striatus / 대한피부과학회지

Lichen striatus is an uncommon, self-limited, unilateral, linear dermatosis of unknown etiology, ordinarily seen in children from 5 to 15 years of age. Clinically lichen striatus consists of a continuous or interrupted band of discrete or confluent, flat-topped, smooth or scaly papules. Multiple lesions are so rare that only 3 cases have been reported in the Korean literature. We reported a rare case of multiple lichen striatus in a 10-year-old girl. She had linear erythematous papules and brownish macules on the lower back, left shoulder, left chest, and left axillar area. The biopsy revealed that spongiosis and vacuolar degeneration in the epidermis, a lichenoid inflammatory infiltrate in the upper dermis and a dense lymphocytic infiltrate around the eccrine glands, ducts and hair follicles. The patient was treated with topical steroid. The lesions disappeared with minor hypopigmentation after 4 months.

A Case of Florid Cutaneous Papillomatosis and Tripe Palm / 대한피부과학회지

Florid cutaneous papillomatosis(FCP) is a disease consisting of multiple acuminate keratotic papules in association with an underlying malignancy. Most common underlying malignancy is gastric adenocarcinoma. Other associated malignancies are breast cancer, bladder cancer, hepatobiliary cancer, ovarian cancer and uterine cancer. An association of FCP with other signs of internal cancer is common, with malignant acanthosis nigricans usually appearing many times with sign of Leser-Trelat. We experienced a florid cutaneous papillomatosis associated gastric adenocarcinoma in an 84 years old woman. The patient had a severe itching and showed numerous tiny papules on the trunk(FCP) and brown verrucose papules on the axillae(acanthosis nigricans) and hyperkeratotic yellowish tiny papules on the palms(tripe palm). Histopathologically, the lesion of the trunk exhibited papillomatosis, hyperkeratosis, and acanthosis in the epidermis. Gastroscopic biopsy revealed gastric adenocarcinoma.