Study on the change and outcome of fasting plasma glucose in elderly people with impaired fasting glucose / 上海预防医学

To study the changes and outcome of fasting plasma glucose and its influ-encing factors in elderly people with impaired fasting glucose ( IFG) . [ Methods] The subjects were a-bove 40 years old and their FPG values were between 6.1 -6.9 mmol/L.The FPG,TC,TG,HDL-C, LDL,height,weight,waist circumference ,hip circumference of the subjects were measured 2 times.A ques-tionnaire about life style and cognition about diabetes was conducted in 2012 among the subjects . [ Results] The IFG subjects were under continuous observation for 2 years.Their overall level of IFG was increased , which was found to be statistically significant .Those diagnosed with diabetes accounted for 9 .85%of the total .Logistic Regression Analysis showed that BMI was the risk factor for IFG subjects in the rise of FPG. [Conclusion] On the whole, for IFG people of 40 or above, overall FGP value was on a growth trend during the past 2 years.The influencing factor is thought to be BMI .

Liver enzymes concentrations are closely related to prediabetes: findings of the Shanghai Diabetes Study II (SHDS II) / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.</p><p><b>METHODS</b>A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.</p><p><b>RESULTS</b>Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00].</p><p><b>CONCLUSION</b>Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.</p>