Progress on diagnose and treatment of blepharokeratoconjunctivitis / 国际眼科杂志(Guoji Yanke Zazhi)

· Blepharokeratoconjunctivitis (BKC) refers to a group of inflammatory lesions secondary to chronic blepharitis in cornea and (or) conjunctiva,is very common in clinic.At the same time,this kind of disease is easily misdiagnosed and missed diagnosed,which causing the management of patient were delayed.The characteristic of BKC is that the patient's condition is prolonged unhealed and unreasonable treatment can result in irreversible damage to the visual function of the patient.In recent years,with the public's understanding of ocular surface diseases has deepened,they also emphasized the influence of BKC to eye health.Although a large number of clinical studies have been carried out on the diagnosis and treatment of BKC,at present there is no unified standard of diagnosis and treatment for it.Consulting the relevant literature and combined with current research status,the diagnosis and treatment of BKC are reviewed in this paper.

Studies on the Screening of a Cyanide-Degradation Strain and Its Cyanide-Transformation Characteristics* / 微生物学通报

A bacterial strain DN25, effective on cyanide-degradation, was isolated from contaminated soil and identified as Alcaligenes sp. on the basis of phenotype analysis and 16S rDNA sequence analysis. It showed great tolerance to the cyanide, which can grow in the medium containing 500mg CN -/L. The suitable condition for the cell growth and boitransformation was pH8.0 and 30oC and the transformation rate for 500mg CN - /L could achieve 99% in 10 h. It has also been found that the screened strain had the ability of K 4Fe(CN) 6 transformation with 96% of transformation rate at 12 h for the concentration of 500 mg CN /L.

ISOLATION OF AN ESTERASE PRODUCER TRICHOSPRONBRASSICAE AND ITS CATALYTIC PERFORMANCE IN KINETICRESOLUTION OF KETOPROFEN / 微生物学通报

A strain of yeast capable of hydrolyzing ethyl ester of racemic Ketoprofen with high enantioselectivity has been isolated from soil after two-step enrichment. The yeast was identified as Trichosporon brassicae. The process of growth and enzyme production was investigated. The catalytic performance of the resting cell of KET4 in kinetic resolution of Ketoprofen was also investigated. When the conversion of substrate reached 41% , enantiomeric excess of the (S) - Ketoprofen produced was 91 % , indicating a high enantiomeric ratio of 45.