ABSTRACT
Objective To analyse the serum levels and clinical significance of interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in patients with acute cerebral infarction.Methods 40 cases of patients with a-cute cerebral infarction were enrolled in this study.The degrees of neurological impairment and infarct volumes of these patiens were evaluated,serum levels of IL-8,TNF-αand hs-CRP were detected as well.40 cases of healthy individuals were selected as con-trol.Results The serum levels of IL-8,TNF-αand hs-CRP in patients with acute cerebral infarction were higher than those in the control group,had statistically significant differences(P <0.05).The serum levels of IL-8,TNF-αand hs-CRP in these patients be-gan to rise at the onset of acute cerebral infarction and reached peak in 72 hours,were also correlated with the volumes of infarction and the degrees of neurologic impairment.14 days after onset of acute cerebral infarction,serum levels of these indexes returned to normal.Conclusion The serum levels of IL-8,TNF-α,hs-CRP are significantly elevated in the patients with acute cerebral infarc-tion,which may be correlated with the volumes of infarction and the degree of neurologic impairment,and could be used to guiding clinical treatment and estimating the severity and prognosis of acute cerebral infarction.