A Clinical Study on Patient with Cerebral Stroke and Diabetes Mellitus

The authors analyzed 72 cerebral stroke with diabetes mellitus who were admitted to our hospital during 1989 to 1993. Pathophysiology and clinical characteristic complication and mortality was analyzed. Followings are results: 1) Among 398 total cerebral stroke who were hospitalized to our hospital during 1989 to 1993, there were 72 cerebral stroke with diabetes(18%). 2) The rate of cerebral infarction and hemorrhage was 67% and 33%. The infarction rate was much higher compared with it of general cerebral stroke. 3) Various complications were presented and mortality rate was 24.% which was regarded higher than it of general cerebral stroke. 4) Association of mortality, prognostic index and other variables were analyzed.

A Case of Primary Epidural Ewing's Sarcoma, Originated in Sacral Area

Recently we experienced a soft tissue sarcoma originated in the spinal epidural space at upper sacral area and extending into intrapelvic area in a young male patient. It was diagnosed primary Ewing's sarcoma histologically. Ewing's sarcoma is usually found in long bones. But rarely discovered in an extraosseous area. So, spinal epidural Ewing's sarcoma is rare to be found. Only 6 cases were reported in the English literature until 1986. We present the case with review of literatures.

Area-Specific Postnatal Maturation of the Calcium-Binding Proteins Parvalbumin- and Calbindin-Immunoreactive Neurons in the Rat Hippocampus

The present study was attempted to obtain the regional differences of development of the parvalbumin- and calbindin-ir neurons in the maturing rat hippocampus. Sprague-Dawley rats at 3, 7 days, 2, 3, 4, 5, 6, and 9 weeks of age were transcardially perfused with 4% paraformaldehyde fixative. The hippocampus was cut into 30 or 40(m sections with a cryostat. Immunohistochemical staining was performed for the parvalbumin and the calbindin using ABC method. The parvalbumin-ir neurons and their axon plexuses achieved the adult patterns as following sequences;CA2 and CA3 at ghe second postnatal week, CA1 at the third week, and dentate granule cell layer by fifth postnatal week. In addition, the calbindin-ir neurons showed the adult patterns by second postnatal week in CA2, CA3, mossy fibers, and the molecular layer of the dentate gyrus, the CA1 at the third week, and finally the dentate granular cell layer by fifth week. These results revealed that time course of the maturation of the parvalbumin- and calbindin-ir neurons in the rat hippocampus showed an area-specificity. The delayed maturation of CA1 and the latest maturation of the dentage granular cell layer suggested that the neurons in these locations seemed to exhibit differential responses to the conditions of increased intracellular calcium, when compared with other areas or with the adult hippocampus.