ABSTRACT
PURPOSE: To identify possible predictors of pathologic complete response (pCR) of rectal cancer after preoperative concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: We conducted a retrospective review of 53 patients with rectal cancer who underwent preoperative CCRT followed by radical surgery at a single center between January 2007 and December 2012. The median radiotherapy dose to the pelvis was 54.0 Gy (range, 45.0 to 63.0 Gy). Five-fluorouracil-based chemotherapy was administered via continuous infusion with leucovorin. RESULTS: The pCR rate was 20.8%. The downstaging rate was 66%. In univariate analyses, poor and undifferentiated tumors (p = 0.020) and an interval of ≥7 weeks from finishing CCRT to surgery (p = 0.040) were significantly associated with pCR, while female gender (p = 0.070), initial carcinoembryonic antigen concentration of <5.0 ng/dL (p = 0.100), and clinical stage T2 (p = 0.100) were marginally significant factors. In multivariate analysis, an interval of ≥7 weeks from finishing CCRT to surgery (odds ratio, 0.139; 95% confidence interval, 0.022 to 0.877; p = 0.036) was significantly associated with pCR, while stage T2 (odds ratio, 5.363; 95% confidence interval, 0.963 to 29.877; p = 0.055) was a marginally significant risk factor. CONCLUSION: We suggest that the interval from finishing CCRT to surgery is a predictor of pCR after preoperative CCRT in patients with rectal cancer. Stage T2 cancer may also be an important predictive factor. We hope to perform a robust study by collecting data during treatment to obtain more advanced results.
Subject(s)
Female , Humans , Carcinoembryonic Antigen , Chemoradiotherapy , Drug Therapy , Hope , Leucovorin , Multivariate Analysis , Pelvis , Polymerase Chain Reaction , Radiotherapy , Rectal Neoplasms , Rectum , Retrospective Studies , Risk FactorsABSTRACT
PURPOSE: To evaluate the clinical results and prognostic factors that predict final visual outcome in eye with posterior segment metallic foreign body(FB) managed by primary pars plana vitrectomy. METHODS: Twenty-nine patients with posterior segment FBs managed by pars plana vitrectomy were reviewed retrospectively. To determine prognostic factors for visual outcomes, variables including ocular findings at presentation, initial visual acuity(VA), location, size and weight of FBs, site of entrance, location of intraretinal lesion, mechanisms of injury and FB removal time were compared with final visual acuity. RESULTS: After a mean follow up of 19.2 months, 15 eyes(52%) achieved VA of 20/40 or better and 5 eyes(17%) showed decreased VA compared to the initial VA. Prognostic factors for the final VA of 20/40 or better included the weight of FBs less than 20 mg, negative findings of retinal detachment and endophthalmitis. Prognostic factors for the final VA of 20/200 or less included the size of FBs more than 4mm, the weight of FBs more than 20 mg, intraretinal FBs, nonhammering as the mechanism of injury. CONCLUSIONS: The predictors of the final VA were the size, the weight and the location of FBs, mechanisms of injury, preoperative negative findings of retinal detachment and endophthalmitis. These factors will be helpful for planning surgery and predicting the prognosis.
Subject(s)
Humans , Endophthalmitis , Follow-Up Studies , Foreign Bodies , Prognosis , Retinal Detachment , Retrospective Studies , Visual Acuity , VitrectomyABSTRACT
PURPOSE: Congenital dacryocystocele is an uncommon variant of congenital nasolacrimal duct obstruction. We report a case of infected congenital dacryocystoceles with nasolacrimal duct cysts bilaterally. METHODS: A 5-day-old girl had bilateral bluish swellings over the lacrimal sacs. Although she had been treated with systemic antibiotics, antibiotic eyedrops and massage, the swelling was not reduced. A computed tomographic (CT) scan demonstrated distension of both lacrimal sacs and nasolacrimal ducts with soft tissue masses beneath the inferior turbinates bilaterally. RESULTS: After marsupialization of bilateral nasolacrimal duct cysts under nasal endoscopic visualization, the swellings over both lacrimal sacs were rapidly resolved without recurrence 3 months thereafter.
Subject(s)
Female , Humans , Anti-Bacterial Agents , Massage , Nasolacrimal Duct , Ophthalmic Solutions , Recurrence , TurbinatesABSTRACT
PURPOSE: To evaluate the effect on intraocular pressure(IOP) of cataract surgery in chronic glaucoma patients. METHODS: We reviewed the change of IOP retrospectively in patients with controlled chronic primary glaucoma who did not show change in the number of glaucoma medications pre- and postoperatively after sutureless phacoemulsification and intraocular lens implantation up to 5 years of follow-up periods. This study included 15 patients with chronic open angle glaucoma and 13 patients with chronic angle closure glaucoma. Mean duration of follow-up period was 39.6 months. RESULTS: The mean preoperative IOP was 15.32 mmHg and mean postoperative IOP was 14.82 mmHg at last follow-up. There was statistically significant difference between pre- and postoperative mean IOP until 1 year postoperatively(p0.05). There was no significant difference in mean IOP during the follow-up period between chronic open angle and chronic angle closure glaucoma. The degree of IOP reduction was statistically significant until 1 year postoperatively but did not thereafter. There was no statistically significant difference in mean IOP reduction between chronic open angle and angle closure glaucoma during the follow-up periods. CONCLUSIONS: These results suggest that intraocular pressure(IOP) after cataract surgery in controlled primary glaucoma patients might be slight reduced up to 1 year postoperatively, but the removal of cataract does not seem to significantly affect IOP level in the long run.