ABSTRACT
A primary sclerosing lipogranuloma of the scrotum is a rare disease, the cause and pathogenesis of which are still unknown. We experienced a 38-year-old man with a painless intrascrotal mass. The mass was firm, and rapidly increased in size in 3 weeks. The patient denied a history of injection of exogenous materials, or of trauma to the scrotum or penis. During the surgical operation, the mass was found to be partly fixed to the scrotal skin, but not to the corpus cavernosum, corpus spongiosum or bilateral spermatic cords. The mass extended deeply into the perineal region. The pathological findings were epithelioid granulomas, with multinucleated giant cells, lymphocytes and eosinophils. Herein, we report a case of a primary sclerosing lipogranuloma in the scrotum.